Cloxapen Side Effects
Generic Name: cloxacillin
Note: This page contains information about the side effects of cloxacillin. Some of the dosage forms included on this document may not apply to the brand name Cloxapen.
Applies to cloxacillin: oral capsule, oral powder for reconstitution
Common gastrointestinal complaints include nausea, vomiting, and diarrhea. Rarely the use of cloxacillin (the active ingredient contained in Cloxapen) has been associated with pseudomembranous colitis.[Ref]
Hematologic adverse effects include neutropenia, leukopenia, and thrombocytopenia. Neutropenia has occurred in 17% of patients and occurs most commonly with higher doses and longer durations of therapy. Neutropenia occurs most often after 14 days of therapy and is reversible upon discontinuation.[Ref]
Hepatic side effects include transient increases in serum transaminases and the development of cholestatic hepatitis. Liver transaminases may take several weeks to return to normal following discontinuation of therapy. Frequent monitoring of liver function tests is recommended in patients with liver disease.[Ref]
Hypersensitivity reactions include rash, fever, eosinophilia, pruritus, fever, chills, and myalgias.[Ref]
1. Pusponegoro EH, Wiryadi BE "Clindamycin and cloxacillin compared in the treatment of skin and soft-tissue infections." Clin Ther 12 (1990): 236-41
2. Westerman EL, Bradshaw MW, Williams TW "Agranulocytosis during therapy with orally administered cloxacillin." Am J Clin Pathol 69 (1978): 559-60
3. Olaison L, Alestig K "A prospective study of neutropenia induced by high doses of B-lactam antiobiotics." J Antimicrob Chemother 25 (1990): 449-53
4. Clotet B, Vea AM, Rubies-Prat J, Sala MF "Cloxacillin-induced leukopenia." Arch Intern Med 145 (1985): 1531
5. Neftel K, Muller MR, Hauser SP, Walti M, de Weck AL "More on penicillin-induced leukopenia." N Engl J Med 308 (1983): 901-2
6. Shah I, Kumar KS, Lerner AM "Agranulocytosis associated with chronic oral administration of cloxacillin for suppression of staphylococcal osteomyelitis." Am J Hematol 12 (1982): 203-6
7. Pascual J, Orofino L, Marcen R, Quereda C, Ortuno J "Cloxacillin-induced cholestasis in a renal allograft patient with chronic hepatitis." Am J Gastroenterol 85 (1990): 335-6
8. Olsson R, Wiholm BE, Sand C, Zettergren L, Hultcrantz R, Myrhed M "Liver damage from flucloxacillin, cloxacillin and dicloxacillin." J Hepatol 15 (1992): 154-61
9. Lotricfurlan S, Lejkozupanc T, Jereb M "Cloxacillin-induced cholestasis." Clin Infect Dis 19 (1994): 981-2
Not all side effects for Cloxapen may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about Cloxapen (cloxacillin)
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.