Cloxapen Side Effects
Generic Name: cloxacillin
Note: This page contains information about the side effects of cloxacillin. Some of the dosage forms included on this document may not apply to the brand name Cloxapen.
Applies to cloxacillin: oral capsule, oral powder for reconstitution
Common gastrointestinal complaints include nausea, vomiting, and diarrhea. Rarely the use of cloxacillin (the active ingredient contained in Cloxapen) has been associated with pseudomembranous colitis.[Ref]
Hematologic adverse effects include neutropenia, leukopenia, and thrombocytopenia. Neutropenia has occurred in 17% of patients and occurs most commonly with higher doses and longer durations of therapy. Neutropenia occurs most often after 14 days of therapy and is reversible upon discontinuation.[Ref]
Hepatic side effects include transient increases in serum transaminases and the development of cholestatic hepatitis. Liver transaminases may take several weeks to return to normal following discontinuation of therapy. Frequent monitoring of liver function tests is recommended in patients with liver disease.[Ref]
Hypersensitivity reactions include rash, fever, eosinophilia, pruritus, fever, chills, and myalgias.[Ref]
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8. Olsson R, Wiholm BE, Sand C, Zettergren L, Hultcrantz R, Myrhed M "Liver damage from flucloxacillin, cloxacillin and dicloxacillin." J Hepatol 15 (1992): 154-61
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Not all side effects for Cloxapen may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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