Skip to Content

Cloxacillin Dosage

Applies to the following strengths: 125 mg/5 mL; 250 mg; 500 mg

Usual Adult Dose for Upper Respiratory Tract Infection

250 mg orally every 6 hours for 7 to 14 days, depending on the nature and severity of the infection.

Maximum dose: 4 g/day.

Usual Adult Dose for Pneumonia

500 mg orally every 6 hours for up to 21 days, depending on the nature and severity of the infection.

Maximum dose: 4 g/day.

Usual Adult Dose for Skin and Structure Infection

500 mg orally every 6 hours for 7 days, or until 3 days after acute inflammation resolves, depending on the nature and severity of the infection.

Maximum dose: 4 g/day.

Usual Adult Dose for Cystitis

250 mg orally every 6 hours for 3 to 7 days, depending on the nature and severity of the infection. Cloxacillin is rarely indicated for the treatment of cystitis.

Maximum dose: 4 g/day.

Usual Pediatric Dose for Pneumonia

The safety and efficacy of cloxacillin in children < 1 year have not been established.

>= 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours.

Maximum dose: 4 g/day.

Usual Pediatric Dose for Upper Respiratory Tract Infection

The safety and efficacy of cloxacillin in children < 1 year have not been established.

>= 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours.

Maximum dose: 4 g/day.

Usual Pediatric Dose for Skin and Structure Infection

The safety and efficacy of cloxacillin in children < 1 year have not been established.

>= 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours.

Maximum dose: 4 g/day.

Other Comments

Cloxacillin is best absorbed when administered on an empty stomach, preferably 1 to 2 hours before meals.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.