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Clorazepate Side Effects

In Summary

More frequently reported side effects include: irritability. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to clorazepate: oral capsule, oral tablet, oral tablet extended release

Along with its needed effects, clorazepate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clorazepate:

Less common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

Get emergency help immediately if any of the following symptoms of overdose occur while taking clorazepate:

Symptoms of overdose
  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • relaxed and calm
  • sleepiness

Some side effects of clorazepate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet

General

The most commonly reported side effect was dizziness.

Psychiatric

Frequency not reported: Insomnia, suicidal ideation/behavior, irritability, depression

Nervous system

Frequency not reported: Dizziness, nervousness, headache, mental confusion, tremor, slurred speech, ataxia[Ref]

Hepatic

Frequency not reported: Abnormal liver function tests

Renal

Frequency not reported: Abnormal kidney function tests

Hematologic

Frequency not reported: Decreased hematocrit

Other

Frequency not reported: Fatigue[Ref]

Dermatologic

Frequency not reported: Transient skin rash

Cardiovascular

Frequency not reported: Decrease in systolic blood pressure

Gastrointestinal

Frequency not reported: Gastrointestinal complaints, dry mouth

Genitourinary

Frequency not reported: Genitourinary complaints

Ocular

Frequency not reported: Blurred vision, diplopia

References

1. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.

Some side effects of clorazepate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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