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Clorazepate Side Effects

Medically reviewed by Last updated on Dec 29, 2019.

In Summary

More frequently reported side effects include: irritability. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to clorazepate: oral tablet


Oral route (Tablet)

Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, or death. Reserve use for patients for whom alternative therapies are inadequate and limit use to lowest possible dose and shortest possible duration. Monitor for signs or symptoms of respiratory depression and sedation.

Side effects requiring immediate medical attention

Along with its needed effects, clorazepate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clorazepate:

Less common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

Get emergency help immediately if any of the following symptoms of overdose occur while taking clorazepate:

Symptoms of overdose

  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • relaxed and calm
  • sleepiness

Side effects not requiring immediate medical attention

Some side effects of clorazepate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet


The most commonly reported side effect was drowsiness.[Ref]

Nervous system

Frequency not reported: Ataxia, dizziness, drowsiness, headache, nervousness, slurred speech[Ref]


Frequency not reported: Depression, insomnia, irritability, mental confusion, suicidal ideation/behavior[Ref]


Frequency not reported: Dry mouth, various gastrointestinal complaints[Ref]


Frequency not reported: Blurred vision, diplopia[Ref]


Frequency not reported: Transient skin rash[Ref]


Frequency not reported: Fatigue[Ref]


Frequency not reported: Genitourinary complaints[Ref]


Frequency not reported: Abnormal liver function tests[Ref]


Frequency not reported: Abnormal kidney function tests[Ref]


Frequency not reported: Decreased hematocrit[Ref]


Frequency not reported: Decrease in systolic blood pressure[Ref]


1. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.