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Clorazepate Side Effects

In Summary

More frequently reported side effects include: irritability. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to clorazepate: oral capsule, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by clorazepate. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking clorazepate:

Less common:
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

If any of the following symptoms of overdose occur while taking clorazepate, get emergency help immediately:

Symptoms of overdose:
  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • relaxed and calm
  • sleepiness

Minor Side Effects

Some of the side effects that can occur with clorazepate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet


The most commonly reported side effect was dizziness.


Frequency not reported: Insomnia, suicidal ideation/behavior, irritability, depression

Nervous system

Frequency not reported: Dizziness, nervousness, headache, mental confusion, tremor, slurred speech, ataxia[Ref]


Frequency not reported: Abnormal liver function tests


Frequency not reported: Abnormal kidney function tests


Frequency not reported: Decreased hematocrit


Frequency not reported: Fatigue[Ref]


Frequency not reported: Transient skin rash


Frequency not reported: Decrease in systolic blood pressure


Frequency not reported: Gastrointestinal complaints, dry mouth


Frequency not reported: Genitourinary complaints


Frequency not reported: Blurred vision, diplopia


1. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.

Not all side effects for clorazepate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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