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Cinoxacin Side Effects

For the Consumer

Applies to cinoxacin: oral capsule

Along with its needed effects, cinoxacin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking cinoxacin:

Less Common


  • black, tarry stools
  • bleeding gums
  • blood in urine or stools
  • Dizziness
  • headache
  • increased sensitivity of skin to sunlight
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Incidence unknown

  • Bone pain
  • lower back or side pain
  • pain, inflammation, or swelling in calves, shoulders, or hands
  • painful, swollen joints
  • seizures

Some side effects of cinoxacin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

For Healthcare Professionals

Applies to cinoxacin: oral capsule


Cinoxacin is generally well tolerated. Adverse effects occur in approximately 5% of treated patients.[Ref]


Cinoxacin most commonly affects the gastrointestinal system, causing nausea, vomiting, and diarrhea in approximately 3% of treated patients.[Ref]

Nervous system

Nervous system toxicity occurs in approximately 2% of patients treated with cinoxacin, and may include headache, dizziness, nervousness, and insomnia. Rarely, blurred vision has been reported. Other adverse effects rarely include paresthesias, somnolence, photophobia, and tinnitus.[Ref]


Hypersensitivity reactions have been reported following cinoxacin administration in approximately 3% of patients. Hypersensitivity reactions most commonly involve rash, urticaria, pruritus, and edema. Anaphylaxis has been reported in a few patients who were previously sensitized to cinoxacin. A case of Henoch-Schonlein purpura has also been reported.[Ref]


Hepatic effects of cinoxacin have rarely included transient elevations of liver function tests.[Ref]


1. "Cinoxacin (Cinobac)--a new drug for urinary tract infections." Med Lett Drugs Ther 23 (1981): 57-8

2. Sisca TS, Heel RC, Romankiewicz JA "Cinoxacin. A review of its pharmacological properties and therapeutic efficacy in the treatment of urinary tract infections." Drugs 25 (1983): 544-69

3. Stamey TA "Cinoxacin: an overview." Urology 17 (1981): 492-5

4. Scavone JM, Gleckman RA, Fraser DG "Cinoxacin: mechanism of action, spectrum of activity, pharmacokinetics, adverse reactions, and therapeutic indications." Pharmacotherapy 2 (1982): 266-72

5. Sabbour MS, El Bokl MA, Osman LM "Experiences on the efficacy and safety of nalidixic acid, oxolinic acid, cinoxacin and norfloxacin in the treatment of urinary tract infections (UTI)." Infection 12 (1984): 377-80

6. Goldstein EJ, Kahn RM, Alpert ML, Ginsberg BP, Greenway FL, Citron DM "Ciprofloxacin versus cinoxacin in therapy of urinary tract infections. A randomized, double-blind trial." Am J Med 82 (1987): 284-7

7. Schaeffer AJ, Flynn S, Jones J "Comparison of cinoxacin and trimethoprim-sulfamethoxazole in the treatment of urinary tract infections." J Urol 125 (1981): 825-7

8. Burt RA "Review of adverse reactions associated with cinoxacin and other drugs used to treat urinary tract infections." Urology 23 (1984): 101-7

9. Cox CE, Simmons JR "Cinoxacin in therapy of urinary tract infections. Comparison of two dosage regimens." Urology 17 (1981): 539-41

10. Cox CE, Simmons JR "Cinoxacin therapy for urinary tract infections: therapeutic safety and efficacy." South Med J 75 (1982): 549-50

11. Drago F, Arditi MR, Rebora A "Henoch-schonlein purpura induced by fluoroquinolones." Br J Dermatol 131 (1994): 448

12. Stricker BH, Slagboom G, Demaeseneer R, Slootmaekers V, Thijs I, Olsson S "Anaphylactic reactions to cinoxacin." BMJ 297 (1988): 1434-5

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.