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Ceftaroline Side Effects

In Summary

Commonly reported side effects of ceftaroline include: positive direct coombs test. Other side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ceftaroline: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by ceftaroline. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ceftaroline, check with your doctor or nurse immediately:

More common:
  • Back, leg, or stomach pains
  • bleeding gums
  • chills
  • dark urine
  • difficulty with breathing
  • fever
  • general body swelling
  • headache
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • pale skin
  • sore throat
  • unusual tiredness or weakness
  • yellowing of the eyes or skin
Less common:
  • Abdominal or stomach tenderness
  • black, tarry stools
  • blood in the urine or stools
  • bluish color
  • changes in skin color
  • chest pain or discomfort
  • confusion
  • convulsions
  • cough
  • decreased frequency or amount of urine
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • general tiredness and weakness
  • hives
  • increased blood pressure
  • increased thirst
  • itching
  • light-colored stools
  • lightheadedness, dizziness, or fainting
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe abdominal or stomach cramps and pain
  • shortness of breath
  • skin itching, rash, or redness
  • slow or irregular heartbeat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, throat, fingers, or lower legs
  • swollen glands
  • tenderness
  • tightness in the chest
  • troubled breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • watery and severe diarrhea, which may also be bloody
  • weakness or heaviness of the legs
  • weight gain
  • wheezing

Minor Side Effects

Some of the side effects that can occur with ceftaroline may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Blurred vision
  • difficulty having a bowel movement (stool)
  • flushed, dry skin fruit-like breath odor
  • hives or welts
  • increased hunger
  • increased urination
  • sweating
  • unexplained weight loss

For Healthcare Professionals

Applies to ceftaroline: intravenous powder for injection

General

The most common side effects reported in adults using this drug were diarrhea, headache, nausea, pruritus, and rash.[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, constipation, vomiting, abdominal pain
Uncommon (0.1% to 1%): Clostridium difficile colitis
Frequency not reported: C difficile-associated diarrhea, dyspepsia[Ref]

Dermatologic

Common (1% to 10%): Rash, pruritus, generalized pruritus
Uncommon (0.1% to 1%): Urticaria[Ref]

In clinical trials using this drug every 12 hours or every 8 hours, rash was common; however, in a subgroup of Asian patients using this drug every 8 hours, rash was very common (18.5%).[Ref]

Metabolic

Common (1% to 10%): Hypokalemia
Frequency not reported: Decreased appetite, hyperglycemia, hyperkalemia[Ref]

Cardiovascular

Common (1% to 10%): Phlebitis, hypertension, increased blood pressure
Frequency not reported: Bradycardia, palpitations[Ref]

Hepatic

Common (1% to 10%): Increased transaminases, increased ALT
Frequency not reported: Abnormal hepatic function, hepatitis, increased AST[Ref]

Hypersensitivity

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported with beta-lactam antibacterials.[Ref]

Uncommon (0.1% to 1%): Hypersensitivity (e.g., urticaria, lip and face swelling), anaphylaxis[Ref]

Renal

Uncommon (0.1% to 1%): Increased blood creatinine
Frequency not reported: Renal failure[Ref]

Hematologic

In clinical trials, direct antiglobulin test seroconversion was reported in 10.7% of adult patients using this drug every 12 hours (600 mg infused over 1 hour every 12 hours) and in 32.3% of those using this drug every 8 hours (600 mg infused over 2 hours every 8 hours). Seroconversion from negative to positive direct Coombs test result was reported in 17.9% of children using this drug.

Agranulocytosis and leukopenia have also been reported during postmarketing experience.[Ref]

Very common (10% or more): Direct antiglobulin test/Coombs test seroconversion (up to 32.3%), positive direct Coombs test
Uncommon (0.1% to 1%): Anemia, leukopenia, neutropenia, thrombocytopenia, prolonged prothrombin time, prolonged activated partial thromboplastin time, increased INR
Rare (0.01% to 0.1%): Agranulocytosis
Frequency not reported: Eosinophilia[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Frequency not reported: Convulsion[Ref]

Other

Common (1% to 10%): Pyrexia, infusion site reactions (e.g., erythema, phlebitis, pain)
Frequency not reported: Asthenia[Ref]

Genitourinary

Frequency not reported: Urinary tract infection[Ref]

Psychiatric

Common (1% to 10%): Insomnia[Ref]

References

1. "Product Information. Teflaro (ceftaroline)." Forest Pharmaceuticals, St. Louis, MO.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. "Ceftaroline fosamil (Teflaro) - a new IV cephalosporin." Med Lett Drugs Ther 53 (2011): 5-6

Not all side effects for ceftaroline may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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