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Ceftaroline Dosage

Applies to the following strength(s): 400 mg ; 600 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Pneumonia

600 mg via IV infusion every 12 hours

Duration of therapy:
-Acute bacterial skin and skin structure infections (ABSSSI): 5 to 14 days
-Community-acquired bacterial pneumonia (CABP): 5 to 7 days

Uses:
-For the treatment of ABSSSI due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, S agalactiae, Escherichia coli, Klebsiella pneumoniae, and K oxytoca
-For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), Haemophilus influenzae, K pneumoniae, K oxytoca, and E coli

Usual Adult Dose for Skin and Structure Infection

600 mg via IV infusion every 12 hours

Duration of therapy:
-Acute bacterial skin and skin structure infections (ABSSSI): 5 to 14 days
-Community-acquired bacterial pneumonia (CABP): 5 to 7 days

Uses:
-For the treatment of ABSSSI due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, S agalactiae, Escherichia coli, Klebsiella pneumoniae, and K oxytoca
-For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), Haemophilus influenzae, K pneumoniae, K oxytoca, and E coli

Usual Pediatric Dose for Pneumonia

2 months to less than 2 years: 8 mg/kg via IV infusion every 8 hours
2 years to less than 18 years (up to 33 kg): 12 mg/kg via IV infusion every 8 hours
2 years to less than 18 years (greater than 33 kg): 400 mg via IV infusion every 8 hours or 600 mg via IV infusion every 12 hours

Duration of therapy: 5 to 14 days

Uses:
-For the treatment of ABSSSI due to susceptible isolates of S aureus (including methicillin-susceptible and -resistant isolates), S pyogenes, S agalactiae, E coli, K pneumoniae, and K oxytoca
-For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), H influenzae, K pneumoniae, K oxytoca, and E coli

Usual Pediatric Dose for Skin and Structure Infection

2 months to less than 2 years: 8 mg/kg via IV infusion every 8 hours
2 years to less than 18 years (up to 33 kg): 12 mg/kg via IV infusion every 8 hours
2 years to less than 18 years (greater than 33 kg): 400 mg via IV infusion every 8 hours or 600 mg via IV infusion every 12 hours

Duration of therapy: 5 to 14 days

Uses:
-For the treatment of ABSSSI due to susceptible isolates of S aureus (including methicillin-susceptible and -resistant isolates), S pyogenes, S agalactiae, E coli, K pneumoniae, and K oxytoca
-For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), H influenzae, K pneumoniae, K oxytoca, and E coli

Renal Dose Adjustments

Adults:
-CrCl greater than 50 mL/min: No adjustment recommended.
-CrCl greater than 30 to 50 mL/min: 400 mg via IV infusion every 12 hours
-CrCl 15 to 30 mL/min: 300 mg via IV infusion every 12 hours
-ESRD (CrCl less than 15 mL/min): 200 mg via IV infusion every 12 hours

Pediatrics:
-CrCl greater than 50 mL/min/1.73 m2: No adjustment recommended.
-CrCl less than 50 mL/min/1.73 m2: Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 2 months.

Consult WARNINGS section for additional precautions.

Dialysis

Adults:
-Hemodialysis: 200 mg IV every 12 hours
-CAPD: Data not available

Comments:
-Because this drug is hemodialyzable, it should be administered after hemodialysis on hemodialysis days.

Pediatrics: Data not available

Other Comments

Administration advice:
-Administer via IV infusion over 5 minutes to 1 hour.
-Therapy duration should be guided by severity and site of infection and by patient's clinical and bacteriological progress.

Storage requirements:
-Unreconstituted vials: Store at 25C (77F); excursions permitted to 15C to 30C (59F to 86F).
-Constituted solution in infusion bag or Baxter(R) Mini-Bag Plus(TM): Store for up to 6 hours at room temperature or for up to 24 hours at 2C to 8C (36F to 46F), including infusion time

Reconstitution/preparation techniques:
-The manufacturer product information should be consulted.
-Final volume for infusion into patients should be between 50 to 250 mL.

IV compatibility:
-Compatible: Sterile water for injection; 0.9% sodium chloride injection; 5% dextrose injection; 2.5% dextrose injection; 0.45% sodium chloride injection; lactated ringer's injection
-Compatibility with other drugs not established; should not mix with or physically add to solutions containing other drugs.

General:
-To reduce the development of drug-resistant organisms and maintain effective therapy, this drug should be used only to treat infections proven or strongly suspected to be caused by susceptible bacteria.
-Appropriate specimens for microbiological testing recommended before therapy to isolate and identify infecting organisms and to establish susceptibility to this drug.
-Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

Patient advice:
-Avoid missing doses and complete the entire course of therapy.
-Contact healthcare provider if severe watery or bloody diarrhea occurs.

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