Carboplatin Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 10, 2020.
Commonly reported side effects of carboplatin include: hypersensitivity reaction, nausea and vomiting, anemia, vomiting, and genitourinary signs and symptoms. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to carboplatin: intravenous powder for solution, intravenous solution
Intravenous route (Solution; Powder for Solution)
Bone marrow suppression with carboplatin is dose-related and may be severe, resulting in infection and/or bleeding. Anemia may be cumulative and may require transfusion support. Vomiting is another frequent drug-related side effect. Anaphylactic-like reactions to carboplatin have been reported and may occur within minutes of carboplatin administration.
Side effects requiring immediate medical attention
Along with its needed effects, carboplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.
Check with your doctor as soon as possible if any of the following side effects occur while taking carboplatin:
- Pain at place of injection
- Black, tarry stools
- blood in urine or stools
- cough or hoarseness, accompanied by fever or chills
- fever or chills
- lower back or side pain, accompanied by fever or chills
- numbness or tingling in fingers or toes
- painful or difficult urination, accompanied by fever or chills
- pinpoint red spots on skin
- skin rash or itching
- unusual bleeding or bruising
- unusual tiredness or weakness
- Blurred vision
- ringing in ears
- sores in mouth and on lips
Side effects not requiring immediate medical attention
Some side effects of carboplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Nausea and vomiting
- unusual tiredness or weakness
This medicine may cause a temporary loss of hair in some people. After treatment with carboplatin has ended, normal hair growth should return.
For Healthcare Professionals
Applies to carboplatin: intravenous powder for injection, intravenous solution
Rare (less than 0.1%): Febrile neutropenia
Frequency not reported: Bone marrow failure, hemolytic-uremic syndrome[Ref]
Common (1% to 10%): Mucositis, diarrhea, constipation
Very common (10% or more): Central neurotoxicity (26%), peripheral neuropathy (15%)
Common (1% to 10%): Other sensory side effects, paresthesia, decrease of osteotendinous reflexes, sensory disturbance, dysgeusia
Very common (10% or more): Alkaline phosphatase elevations (29%), SGOT elevations (20%), aspartate aminotransferase increased, liver function test abnormal
Common (1% to 10%): Bilirubin elevations[Ref]
Very common (10% or more): Blood urea elevations (17%), creatinine renal clearance decreased[Ref]
Very common (10% or more): Pain (44%), asthenia (41%), ototoxicity (12%)
Common (1% to 10%): Asthenia
Frequency not reported: Malaise[Ref]
Common (1% to 10%): Hypersensitivity, anaphylactoid type reaction[Ref]
Very common (10% or more): Magnesium loss (61%), potassium loss (16%), calcium loss (16%), sodium loss (10%)
Rare (less than 0.1%): Hyponatremia
Rare (less than 0.1%): Visual disturbance (including rare cases of loss of vision)[Ref]
Very common (10% or more): Infection (14%)
Frequency not reported: Injection site necrosis, injection site reaction, injection site extravasation, injection site erythema
Common (1% to 10%): Musculoskeletal disorder[Ref]
Common (1% to 10%): Urogenital disorder[Ref]
Frequency not reported: Neoplasms (e.g., benign, malignant, unspecified) including cysts and polyps[Ref]
Common (1% to 10%): Respiratory disorder, interstitial lung disease, bronchospasm
Common (1% to 10%): Cardiovascular disorder
Very common (10% or more): Alopecia (49%), skin disorder
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.