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Capastat Sulfate Side Effects

Generic Name: capreomycin

Note: This document contains side effect information about capreomycin. Some of the dosage forms listed on this page may not apply to the brand name Capastat Sulfate.

For the Consumer

Applies to capreomycin: injection powder for solution

Along with its needed effects, capreomycin (the active ingredient contained in Capastat Sulfate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking capreomycin:

More common
  • Black, tarry stools
  • blood in the urine
  • change in the frequency of urination or amount of urine
  • chest pain
  • chills
  • cough
  • difficult breathing
  • dizziness
  • drowsiness
  • feeling of fullness in the ears
  • fever
  • increased thirst
  • loss of appetite
  • loss of balance
  • loss of hearing
  • nausea or vomiting
  • painful or difficult urination
  • ringing or buzzing in the ears
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the feet or lower legs
  • swollen glands
  • trouble with hearing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • Bleeding gums
  • pinpoint red spots on the skin
Incidence not known
  • Abdominal or stomach cramps
  • confusion
  • continuous ringing or buzzing or other unexplained noise in the ears
  • convulsions
  • decreased urine
  • dizziness or lightheadedness
  • dry mouth
  • feeling of constant movement of self or surroundings
  • irregular heartbeats
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle spasms (tetany) or twitching
  • numbness and tingling around the mouth, fingertips, or feet
  • sensation of spinning
  • tremor

Some side effects of capreomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Hives or welts, itching, or skin rash
  • pain, bleeding, or hard lump at the injection site
  • redness of the skin

For Healthcare Professionals

Applies to capreomycin: intramuscular powder for injection


Renal side effects have included dose-related nephrotoxicity, including BUN elevations (greater than 20 mg/dL) (36%), BUN elevations (greater than 30 mg/dL) (10%), depression of PSP excretion, abnormal urine sediment, renal insufficiency, and oliguria. At least one case of toxic nephritis and acute tubular necrosis has been reported.[Ref]

A patient with tuberculosis and portal cirrhosis experienced toxic nephritis and acute tubular necrosis coincident with capreomycin therapy. The patient was treated with capreomycin therapy (1 g) and aminosalicylic acid daily for 1 month. The patient developed renal insufficiency and oliguria and died. The autopsy showed subsiding acute tubular necrosis.[Ref]

Nervous system

Nervous system side effects have included ototoxicity and vestibular toxicity including subclinical auditory loss (11%), clinically apparent hearing loss (3%), vertigo, and tinnitus.[Ref]


Local side effects have included pain, induration, and excessive bleeding at the injection site.[Ref]


Hematologic side effects have included leukocytosis, leukopenia, and eosinophilia. Thrombocytopenia has also been reported rarely.[Ref]


Hepatic side effects have included decreased BSP excretion.[Ref]


Metabolic side effects including hypokalemia, hypocalcemia, hypomagnesemia, and electrolyte disturbances resembling Bartter's syndrome have been reported.[Ref]


1. "Product Information. Capastat Sulfate (capreomycin)." Dura Pharmaceuticals, San Diego, CA.

Some side effects of Capastat Sulfate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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