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Capastat Sulfate Side Effects

Generic name: capreomycin

Medically reviewed by Last updated on Apr 29, 2023.

Note: This document contains side effect information about capreomycin. Some dosage forms listed on this page may not apply to the brand name Capastat Sulfate.

Applies to capreomycin: injection powder for solution.


Injection route (Powder for Solution)

The use of capreomycin may be associated with worse clinical outcomes, ie, decreased effectiveness and increased mortality, compared with other parenteral therapy for pulmonary multidrug-resistant tuberculosis (MDR-TB). In patients who require parenteral treatment for pulmonary MDR-TB, reserve capreomycin for those with resistance to injectable aminoglycosides and limited treatment options.The use of capreomycin in patients with renal insufficiency or preexisting auditory impairment must be undertaken with great caution, and the risk of additional cranial nerve VIII impairment or renal injury should be weighed against the benefits to be derived from therapy.Since other parenteral antituberculosis agents (streptomycin, viomycin) also have similar and sometimes irreversible toxic effects, particularly on cranial nerve VIII and renal function, simultaneous administration of these agents with capreomycin is not recommended. Use with other drugs (polymyxin A sulfate, colistin sulfate, amikacin, gentamicin, tobramycin, vancomycin, kanamycin, and neomycin) having ototoxic or nephrotoxic potential should be undertaken only with great caution.

Serious side effects of Capastat Sulfate

Along with its needed effects, capreomycin (the active ingredient contained in Capastat Sulfate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking capreomycin:

More common


Incidence not known

Other side effects of Capastat Sulfate

Some side effects of capreomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to capreomycin: intramuscular powder for injection.


The most commonly reported side effects included blood urea nitrogen (BUN) elevations above 20 mg/100 mL, subclinical hearing loss, and eosinophilia.[Ref]


Very common (10% or more): BUN elevation above 20 mg/100 mL (up to 26%)

Common (1% to 10%): BUN elevation above 30 mg/100 mL

Frequency not reported: Acute tubular necrosis, depression of phenolsulfonphthalein (PSP) excretion, oliguria, renal insufficiency, toxic nephritis[Ref]

A fatal case of renal insufficiency and oliguria occurred in a patient with tuberculosis and portal cirrhosis treated with 1 g of this drug and aminosalicylic acid daily for 1 month. Toxic nephritis was reported, and autopsy showed subsiding acute tubular necrosis.[Ref]


Very common (10% or more): Subclinical auditory loss (up to 11%)

Common (1% to 10%): Clinically apparent hearing loss

Frequency not reported: Death, febrile reaction, ototoxicity, tinnitus[Ref]


Rare (0.01% to 0.1%): Thrombocytopenia

Frequency not reported: Eosinophilia, leukocytosis, leukopenia[Ref]


Frequency not reported: Excessive bleeding at injection site, injection site induration, injection site pain, sterile abscesses[Ref]


Frequency not reported: Electrolyte disturbances, hypocalcemia, hypokalemia, hypomagnesemia[Ref]


Frequency not reported: Abnormal liver function tests, decrease in bromsulphalein (BSP) excretion[Ref]


Frequency not reported: Maculopapular skin rashes, urticaria[Ref]

Nervous system

Frequency not reported: Vertigo[Ref]


Frequency not reported: Abnormal urine sediment[Ref]


1. Product Information. Capastat Sulfate (capreomycin). Dura Pharmaceuticals. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.