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Calcitrene Side Effects

Generic name: calcipotriene topical

Medically reviewed by Last updated on Apr 9, 2021.

Note: This document contains side effect information about calcipotriene topical. Some of the dosage forms listed on this page may not apply to the brand name Calcitrene.

In Summary

Common side effects of Calcitrene include: skin irritation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to calcipotriene topical: topical cream, topical foam, topical ointment, topical solution

Side effects requiring immediate medical attention

Along with its needed effects, calcipotriene topical (the active ingredient contained in Calcitrene) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking calcipotriene topical:

More common

Get emergency help immediately if any of the following symptoms of overdose occur while taking calcipotriene topical:

Symptoms of overdose

  • Confusion
  • constipation
  • discouragement
  • dry mouth
  • feeling sad or empty
  • headache
  • incoherent speech
  • increased urination
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • metallic taste
  • muscle weakness
  • nausea
  • stomach pain
  • thirst
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unusual tiredness
  • vomiting
  • weight loss

Side effects not requiring immediate medical attention

Some side effects of calcipotriene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Burning, dryness, irritation, peeling, or redness of the skin

Less common

  • Pain at the application site


  • Darker color in the treated areas of the skin
  • pus in the hair follicles

For Healthcare Professionals

Applies to calcipotriene topical: topical cream, topical foam, topical ointment, topical solution


The most commonly reported side effects were burning, stinging, tingling, and skin irritation.[Ref]


Very rare (less than 0.01%): Allergic reactions (including angioedema)[Ref]


Very common (10% or more): Transient burning (about 23%), stinging (about 23%), tingling (about 23%), skin irritation (up to 15%), rash (11%)

Common (1% to 10%): Pruritus, dermatitis, contact dermatitis (including facial and perioral), dry skin, irritation, worsening of psoriasis, erythema, peeling

Uncommon (0.1% to 1%): Skin atrophy, hyperpigmentation, folliculitis, eczema

Frequency not reported: Transient changes in skin pigmentation, transient photosensitivity, urticaria, angioedema, skin exfoliation[Ref]


Uncommon (0.1% to 1%): Hypercalcemia

Rare (less than 0.1%): Transient increases in serum calcium

Very rare (less than 0.01%): Hypercalcemia, hypercalciuria (especially if the total recommended dose is exceeded)[Ref]


Very common (10% or more): Lesional/perilesional irritation (up to 39%), face and/or scalp irritation (up to 25%)[Ref]


Frequency not reported: Periorbital or face edema[Ref]


1. "Product Information. Dovonex (calcipotriene)." Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.