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Brodalumab Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 4, 2020.

In Summary

Commonly reported side effects of brodalumab include: infection. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brodalumab: subcutaneous solution

Warning

Subcutaneous route (Solution)

Suicidal ideation and behavior, including completed suicides, have occurred with brodalumab. Weigh potential risks and benefits in each patient prior to initiation, and advise patients and caregivers to seek medical attention for new or worsening depression, anxiety, or other mood changes. Refer patients with new or worsening suicidal ideation and behavior to a mental health professional. Brodalumab is only available through a restricted program called the Siliq REMS Program.

Side effects requiring immediate medical attention

Along with its needed effects, brodalumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brodalumab:

Less common

  • Black, tarry stools
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • painful or difficult urination
  • pale skin
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • thoughts of killing oneself
  • trouble concentrating
  • trouble sleeping

Side effects not requiring immediate medical attention

Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Difficulty with moving
  • muscle pain or stiffness
  • pain in the joints
  • pain, redness, burning, or itching at the injection site

For Healthcare Professionals

Applies to brodalumab: subcutaneous solution

Gastrointestinal

Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea[Ref]

Hematologic

Common (1% to 10%): Neutropenia[Ref]

Genitourinary

Frequency not reported: Urinary tract infection[Ref]

Other

Common (1% to 10%): Fatigue[Ref]

Immunologic

Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity

Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)[Ref]

Local

Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, myalgia[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis[Ref]

Respiratory

Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis[Ref]

Psychiatric

Uncommon (0.1% to 1%): Suicidal ideation or behavior[Ref]

References

1. "Product Information. Siliq (brodalumab)." Valeant Pharmaceuticals, Costa Mesa, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.