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Brodalumab Side Effects

Medically reviewed by Last updated on Jun 13, 2023.

Applies to brodalumab: subcutaneous solution.


Subcutaneous route (Solution)

Suicidal ideation and behavior, including completed suicides, have occurred with brodalumab. Weigh potential risks and benefits in each patient prior to initiation, and advise patients and caregivers to seek medical attention for new or worsening depression, anxiety, or other mood changes. Refer patients with new or worsening suicidal ideation and behavior to a mental health professional. Brodalumab is only available through a restricted program called the Siliq REMS Program.

Serious side effects of Brodalumab

Along with its needed effects, brodalumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brodalumab:

Less common

Incidence not known

Other side effects of Brodalumab

Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to brodalumab: subcutaneous solution.


Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea[Ref]


Common (1% to 10%): Neutropenia[Ref]


Frequency not reported: Urinary tract infection[Ref]


Common (1% to 10%): Fatigue[Ref]


Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity

Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)[Ref]


Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)[Ref]


Common (1% to 10%): Arthralgia, myalgia[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Uncommon (0.1% to 1%): Conjunctivitis[Ref]


Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis[Ref]


Uncommon (0.1% to 1%): Suicidal ideation or behavior[Ref]

Frequently asked questions


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2017) "Product Information. Siliq (brodalumab)." Valeant Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.