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Brevital Sodium Side Effects

Generic name: methohexital

Note: This document contains side effect information about methohexital. Some of the dosage forms listed on this page may not apply to the brand name Brevital Sodium.

For the Consumer

Applies to methohexital: injectable powder for injection, intravenous solution


You should not use this medicine if you have a history of porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • severe burning or swelling where the medicine was injected;

  • fast heartbeats;

  • numbness or tingly feeling;

  • a light-headed feeling, like you might pass out;

  • weak or shallow breathing; or

  • confusion, anxiety, or restless feeling when coming out of anesthesia.

Side effects such as confusion, depression, or excitement may be more likely in older adults and those who are ill or debilitated.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to methohexital: injectable powder for injection, intravenous powder for injection, intravenous solution


Frequency not reported: Circulatory depression, hypotension, tachycardia, peripheral vascular collapse, convulsions (associated with cardiorespiratory arrest)[Ref]


Frequency not reported: Respiratory depression (including apnea), cardiorespiratory arrest, laryngospasm, bronchospasm, hiccups, dyspnea, rhinitis[Ref]

Nervous system

Frequency not reported: Injury to nerves adjacent to injection site, seizure, headache[Ref]


Frequency not reported: Emergence delirium, restlessness, and anxiety (especially in the presence of postoperative pain)[Ref]


Frequency not reported: Nausea, vomiting, abdominal pain, salivation[Ref]


Rare (less than 0.1%): Anaphylaxis[Ref]


Frequency not reported: Liver function tests abnormal[Ref]


Frequency not reported: Injection site pain[Ref]


Frequency not reported: Thrombophlebitis[Ref]


Frequency not reported: Skeletal muscle hyperactivity (twitching)[Ref]


Frequency not reported: Erythema, pruritus, urticaria[Ref]


1. "Product Information. Brevital Sodium (methohexital)." Par Pharmaceutical Inc, Chestnut Ridge, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.