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Brevital Sodium Side Effects

Generic Name: methohexital

Note: This page contains information about the side effects of methohexital. Some of the dosage forms included on this document may not apply to the brand name Brevital Sodium.

For the Consumer

Applies to methohexital: intravenous powder for injection, intravenous solution

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • severe burning or swelling where the medicine was injected;

  • fast heartbeats;

  • numbness or tingly feeling;

  • a light-headed feeling, like you might pass out;

  • weak or shallow breathing; or

  • confusion, anxiety, or restless feeling when coming out of anesthesia.

Side effects such as confusion, depression, or excitement may be more likely in older adults and those who are ill or debilitated.

Common side effects may include:

  • drowsiness;

  • nausea, vomiting, stomach pain;

  • chills or shivering;

  • coughing, hiccups;

  • muscle twitching; or

  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to methohexital: intravenous powder for injection, intravenous solution


Cardiovascular side effects have included circulatory depression, thrombophlebitis, hypotension, tachycardia, peripheral vascular collapse, and convulsions in association with cardiorespiratory arrest.[Ref]


Respiratory side effects have included respiratory depression (including apnea), cardiorespiratory arrest, laryngospasm, bronchospasm, hiccups, and dyspnea.[Ref]

Nervous system

Nervous system side effects have included headache, skeletal muscle hyperactivity (twitching), and seizures.[Ref]


Psychiatric side effects have included emergence delirium, restlessness, and anxiety, especially in the presence of postoperative pain.[Ref]


Gastrointestinal side effects have included nausea, emesis, salivation, and abdominal pain.[Ref]


Hypersensitivity side effects have included erythema, pruritus, urticaria, and cases of anaphylaxis.[Ref]


Hepatic side effects have included abnormal liver function tests.[Ref]


Local side effects have included injury to nerves adjacent to injection site and pain at injection site.[Ref]


1. "Product Information. Brevital Sodium (methohexital)." JHP Pharmaceuticals, Saddle River, NJ.

Not all side effects for Brevital Sodium may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.