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Bivalirudin Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 23, 2024.

Applies to bivalirudin: intravenous powder for solution, intravenous solution.

Serious side effects of Bivalirudin

Along with its needed effects, bivalirudin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking bivalirudin:

More common

Less common

Rare

Incidence not known

Other side effects of Bivalirudin

Some side effects of bivalirudin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to bivalirudin: intravenous powder for injection, intravenous solution.

Cardiovascular

Common (1% to 10%): Atrial fibrillation, ventricular tachycardia, angina pectoris, bradycardia, hypertension, hypotension, chest pain

Rare (less than 0.1%): Myocardial infarction, cardiac tamponade, pericardial hemorrhage, coronary artery thrombosis, coronary stent thrombosis (including reports with fatal outcome), arteriovenous fistula, catheter thrombosis, vascular pseudoaneurysm

Postmarketing reports: Cardiac tamponade, ventricular fibrillation[Ref]

Respiratory

Uncommon (0.1% to 1%): Epistaxis, hemoptysis, pharyngeal hemorrhage

Rare (less than 0.1%): Pulmonary hemorrhage, dyspnea[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, urticaria[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, dyspepsia

Uncommon (0.1% to 1%): GI hemorrhage (i.e., hematemesis, melena, esophageal hemorrhage, anal hemorrhage), retroperitoneal hemorrhage, gingival hemorrhage

Rare (less than 0.1%): Retroperitoneal hematoma[Ref]

Genitourinary

Uncommon (0.1% to 1%): Hematuria[Ref]

Hematologic

Very common (10% or more): Minor hemorrhage at any site (22%)

Common (1% to 10%): Hemoglobin decreased, major hemorrhage at any site (including fatal outcomes)

Uncommon (0.1% to 1%): Thrombocytopenia, anemia, hematoma

Rare (less than 0.1%): INR increased

Postmarketing reports: Catheter thrombosis, arteriovenous fistula, compartment syndrome[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Anaphylaxis (including fatal shock)[Ref]

Local

Common (1% to 10%): Access site hemorrhage, vessel puncture site hematoma (5 cm or less), vessel puncture site hematoma (greater than 5 cm), injection site pain

Rare (less than 0.1%): Injection site reactions (i.e., injection site discomfort, injection site pain, puncture site reaction)[Ref]

Musculoskeletal

Very common (10% or more): Back pain

Common (1% to 10%): Chest pain[Ref]

Nervous system

Common (1% to 10%): Headache, insomnia

Rare (less than 0.1%): Intracranial hemorrhage[Ref]

Ocular

Rare (less than 0.1%): Intraocular hemorrhage[Ref]

Other

Rare (less than 0.1%): Ear hemorrhage[Ref]

Psychiatric

Common (1% to 10%): Nervousness[Ref]

References

1. (2001) "Product Information. Angiomax (bivalirudin)." The Medicines Company

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. (2016) "Product Information. Bivalirudin (bivalirudin)." Fresenius Kabi USA, LLC

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.