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Bicillin C-R Side Effects

Generic Name: penicillin g benzathine / procaine penicillin

Note: This document contains side effect information about penicillin g benzathine / procaine penicillin. Some of the dosage forms listed on this page may not apply to the brand name Bicillin C-R.

For the Consumer

Applies to penicillin g benzathine / procaine penicillin: intramuscular suspension

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Fever or chills.
  • Swelling.
  • Joint pain.
  • Very bad dizziness or passing out.
  • Feeling very tired or weak.
  • Any unexplained bruising or bleeding.
  • It is common to have diarrhea when taking this drug. Rarely, a very bad form of diarrhea called Clostridium difficile (C diff)–associated diarrhea (CDAD) may occur. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen while you are taking this drug or within a few months after you stop taking it. Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools. Do not try to treat loose stools without first checking with your doctor.
  • Nerve damage can happen if this drug is given into or near a nerve. This could be long-lasting. Call your doctor right away if you have any numbness, tingling, or weakness.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Loose stools (diarrhea).

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to penicillin g benzathine / procaine penicillin: intramuscular suspension

Psychiatric

Hoigne's syndrome, characterized by various central nervous system symptoms (e.g., severe agitation with confusion, visual and auditory hallucinations, fear of impending death), has been reported after use of procaine penicillin, and less commonly, after use of this drug. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.[Ref]

Frequency not reported: Hoigne's syndrome (including severe agitation with confusion, visual and auditory hallucinations, fear of impending death, psychosis)

Parenteral Penicillin G Benzathine:
-Frequency not reported: Nervousness, confusion, anxiety, euphoria[Ref]

Nervous system

Frequency not reported: Symptoms associated with Hoigne's syndrome (including seizures, dizziness, tinnitus, abnormal taste perception)

Parenteral Penicillin G:
-Frequency not reported: Neuropathy

Parenteral Penicillin G Benzathine:
-Frequency not reported: Headache, tremors, dizziness, somnolence, transverse myelitis, seizures, coma, vasovagal reaction, cerebrovascular accident, syncope[Ref]

Cardiovascular

Frequency not reported: Symptoms associated with Hoigne's syndrome (including cyanosis, palpitations, tachycardia)

Parenteral Penicillin G Benzathine:
-Frequency not reported: Cardiac arrest, hypotension, tachycardia, palpitations, vasodilation[Ref]

Hypersensitivity

Parenteral Penicillin G:
-Frequency not reported: Hypersensitivity reactions (including skin eruptions [maculopapular to exfoliative dermatitis], urticaria, laryngeal edema, fever, eosinophilia, other serum sickness-like reactions [including chills, fever, edema, arthralgia, prostration], anaphylaxis [including shock, death])

Parenteral Penicillin G Benzathine:
-Frequency not reported: Hypersensitivity reactions (including allergic vasculitis, pruritus, fatigue, asthenia, pain)[Ref]

Gastrointestinal

Onset of pseudomembranous colitis symptoms have been reported during or after antibacterial therapy.[Ref]

Parenteral Penicillin G:
-Frequency not reported: Clostridium difficile-associated diarrhea, pseudomembranous colitis

Parenteral Penicillin G Benzathine:
-Frequency not reported: Nausea, vomiting, blood in stool, intestinal necrosis[Ref]

Renal

Parenteral Penicillin G:
-Frequency not reported: Nephropathy

Parenteral Penicillin G Benzathine:
-Frequency not reported: Elevated BUN, elevated creatinine, renal failure[Ref]

Hematologic

Parenteral Penicillin G:
-Frequency not reported: Hemolytic anemia, leukopenia, thrombocytopenia

Parenteral Penicillin G Benzathine:
-Frequency not reported: Lymphadenopathy[Ref]

Local

Parenteral Penicillin G Benzathine:
-Frequency not reported: Injection site reactions (including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, skin ulcer), neurovascular reactions (including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, neurovascular damage)[Ref]

Respiratory

Parenteral Penicillin G Benzathine:
-Frequency not reported: Hypoxia, apnea, dyspnea, pulmonary hypertension, pulmonary embolism[Ref]

Hepatic

Parenteral Penicillin G Benzathine:
-Frequency not reported: Elevated AST[Ref]

Musculoskeletal

Parenteral Penicillin G Benzathine:
-Frequency not reported: Joint disorder, periostitis, myoglobinuria, rhabdomyolysis, exacerbation of arthritis[Ref]

Ocular

Parenteral Penicillin G Benzathine:
-Frequency not reported: Blurred vision, blindness[Ref]

Genitourinary

Parenteral Penicillin G Benzathine:
-Frequency not reported: Neurogenic bladder, hematuria, proteinuria, impotence, priapism[Ref]

Other

Parenteral Penicillin G Benzathine:
-Frequency not reported: Aggravation of existing disorder[Ref]

Dermatologic

Parenteral Penicillin G Benzathine:
-Frequency not reported: Diaphoresis[Ref]

References

1. "Product Information. Bicillin C-R 900/300 (benzathine penicillin-procaine penicillin)." Wyeth Laboratories, Philadelphia, PA.

2. "Product Information. Bicillin C-R (benzathine penicillin-procaine penicillin)." A-S Medication Solutions, Chicago, IL.

Some side effects of Bicillin C-R may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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