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Bicillin C-R Side Effects

Generic Name: penicillin g benzathine / procaine penicillin

Note: This page contains information about the side effects of penicillin g benzathine / procaine penicillin. Some of the dosage forms included on this document may not apply to the brand name Bicillin C-R.

For the Consumer

Applies to penicillin g benzathine / procaine penicillin: intramuscular suspension

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Fever or chills.
  • Swelling.
  • Joint pain.
  • Very bad dizziness or passing out.
  • Feeling very tired or weak.
  • Any unexplained bruising or bleeding.
  • It is common to have diarrhea when taking this drug. Rarely, a very bad form of diarrhea called Clostridium difficile (C diff)–associated diarrhea (CDAD) may occur. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen while you are taking this drug or within a few months after you stop taking it. Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools. Do not try to treat loose stools without first checking with your doctor.
  • Nerve damage can happen if this drug is given into or near a nerve. This could be long-lasting. Call your doctor right away if you have any numbness, tingling, or weakness.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Loose stools (diarrhea).

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to penicillin g benzathine / procaine penicillin: intramuscular suspension

Hypersensitivity

Hypersensitivity side effects associated with parenteral penicillin G have included skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia, other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration), and anaphylaxis (including shock and death). Hypersensitivity reactions including allergic vasculitis, pruritus, fatigue, asthenia, and pain have been temporally associated with parenteral penicillin G benzathine use.[Ref]

Nervous system

Nervous system side effects associated with parenteral penicillin G have included neuropathy. Headache, tremors, dizziness, somnolence, transverse myelitis, seizures, and coma have been temporally associated with parenteral penicillin G benzathine use.[Ref]

Gastrointestinal

The onset of pseudomembranous colitis symptoms may occur during or after treatment.[Ref]

Gastrointestinal side effects associated with parenteral penicillin G have included pseudomembranous colitis. Nausea, vomiting, blood in stool, and intestinal necrosis have been temporally associated with parenteral penicillin G benzathine use.[Ref]

Psychiatric

Psychiatric side effects temporally associated with parenteral penicillin G benzathine have included nervousness, confusion, anxiety, and euphoria. A syndrome manifested by a variety of central nervous system symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome) has been reported following procaine penicillin use, and less commonly, following benzathine penicillin-procaine penicillin use. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.[Ref]

Cardiovascular

Cardiovascular side effects temporally associated with parenteral penicillin G benzathine have included cardiac arrest, hypotension, tachycardia, palpitations, pulmonary hypertension, pulmonary embolism, vasodilation, vasovagal reaction, cerebrovascular accident, and syncope.[Ref]

Renal

Renal side effects associated with parenteral penicillin G have included nephropathy. Elevated BUN, elevated creatinine, and renal failure have been temporally associated with parenteral penicillin G benzathine use.[Ref]

Hematologic

Hematologic side effects associated with parenteral penicillin G have included hemolytic anemia, leukopenia, and thrombocytopenia. Lymphadenopathy has been temporally associated with parenteral penicillin G benzathine use.[Ref]

Local

Local side effects temporally associated with parenteral penicillin G benzathine have included injection site reactions, including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage have been temporally associated with parenteral penicillin G benzathine use.[Ref]

Respiratory

Respiratory side effects temporally associated with parenteral penicillin G benzathine have included hypoxia, apnea, and dyspnea.[Ref]

Hepatic

Hepatic side effects temporally associated with parenteral penicillin G benzathine have included elevated serum glutamic oxaloacetic transaminase (SGOT).[Ref]

Musculoskeletal

Musculoskeletal side effects temporally associated with parenteral penicillin G benzathine have included joint disorder, periostitis, myoglobinuria, rhabdomyolysis, and exacerbation of arthritis.[Ref]

Ocular

Ocular side effects temporally associated with parenteral penicillin G benzathine have included blurred vision and blindness.[Ref]

Genitourinary

Genitourinary side effects temporally associated with parenteral penicillin G benzathine have included neurogenic bladder, hematuria, proteinuria, impotence, and priapism.[Ref]

Other

Other side effects temporally associated with parenteral penicillin G benzathine have included aggravation of existing disorder.[Ref]

Dermatologic

Dermatologic side effects temporally associated with parenteral penicillin G benzathine have included diaphoresis.[Ref]

References

1. "Product Information. Bicillin C-R 900/300 (benzathine penicillin-procaine penicillin)." Wyeth Laboratories, Philadelphia, PA.

Not all side effects for Bicillin C-R may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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