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Bicillin C-R

Generic name: penicillin G benzathine and penicillin G procainePEN-i-SILL-in-G-BEN-za-theen-and-PEN-i-SILL-in-G-PRO-kane ]
Brand names: Bicillin C-R, Bicillin C-R 900/300
Drug class: Natural penicillins

Medically reviewed by on Jun 3, 2024. Written by Cerner Multum.

What is Bicillin C-R?

Bicillin C-R is a combination antibiotic that is used to treat infections caused by bacteria, including strep, pneumonia, and scarlet fever.

Bicillin C-R may also be used for purposes not listed in this medication guide.

Bicillin C-R side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Some side effects may occur if the medicine has been accidentally injected near a vein or nerve. Tell your caregivers right away if you feel light-headed or if you have:

Also call your doctor at once if you have:

Seek medical attention right away if you develop a serious condition called methemoglobinemia. Symptoms include headache, fast heartbeats, shortness of breath, feeling tired or light-headed, or skin that looks pale, gray, or blue-colored.

Common side effects of Bicillin C-R may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Tell your caregivers right away if you feel light-headed during the injection.

Before taking this medicine

You should not be treated with this medicine if you are allergic to penicillin or procaine.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How is Bicillin C-R given?

Bicillin C-R is injected into a muscle by a healthcare provider.

This medicine is sometimes given in a single dose. The medicine may also be given every 2 to 3 days until your body temperature is normal for 48 hours.

Keep receiving the medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication.

You may need tests after treatment to make sure your infection has completely cleared.

If you need a medical, dental, or surgical procedure that includes use of a numbing medicine applied to one area of the body (local), tell the doctor ahead of time if you have recently received a Bicillin C-R injection.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause a seizure.

What should I avoid while receiving Bicillin C-R?

Avoid taking anti-diarrhea medicine without first asking your doctor. Diarrhea may be a sign of a new infection.

What other drugs will affect Bicillin C-R?

Tell your doctor about all your other medicines, especially:

This list is not complete and many other drugs may affect Bicillin C-R. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.