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Bempedoic acid Side Effects

Medically reviewed by Last updated on March 16, 2020.

For the Consumer

Applies to bempedoic acid: oral tablet


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking bempedoic acid and seek medical attention right away if you have signs of tendon rupture:

  • sudden pain, swelling, bruising, or tenderness;

  • stiffness, movement problems; or

  • or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).

Call your doctor at once if you have:

  • severe foot or toe pain;

  • joint pain or swelling;

  • warmth or redness over your joints; or

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to bempedoic acid: oral tablet


The more commonly reported adverse reactions have included upper respiratory tract infections, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, extremity pain, anemia, and elevated liver enzymes.[Ref]


Very common (10% or more): Hyperuricemia (26%)

Common (1% to 10%): Clinically significant hyperuricemia, gout

Uncommon (0.1% to 1%): Increase in creatine kinase

Gout occurred in 1.5% of patients receiving this drug compared to 0% of placebo-treated patients.


Common (1% to 10%): Muscle spasms, back pain, extremity pain

Uncommon (0.1% to 1%): Tendon rupture


Common (1% to 10%): Upper respiratory tract infection, bronchitis


Common (1% to 10%): Anemia, decreased leukocytes, increased platelet counts

Approximately 10.1% of patients had an increase in platelet count of 100x10(9)/L or more on 1 or more occasion compared to 4.7% receiving placebo. Platelet count elevations appeared to be asymptomatic as they did not result in an increased risk of thromboembolic events or require medical intervention.


Common (1% to 10%): Benign prostatic hyperplasia

Benign prostatic hyperplasia or prostatomegaly was reported in 1.3% of patients receiving this drug versus 0.1% in placebo patients.


Common (1% to 10%): Abdominal pain or discomfort

Frequency not reported: Diarrhea


Common (1% to 10%): Elevated liver enzymes


Common (1% to 10%): Increased BUN, increased creatinine values


Common (1% to 10%): Atrial fibrillation

Atrial fibrillation was reported in 1.7% of patients receiving this drug compared with 1.1% of placebo-treated patients.


Rare (less than 0.1%): Cellulitis


1. "Product Information. Nexletol (bempedoic acid)." Esperion Therapeutics, Ann Arbor, MI.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.