Bempedoic Acid Dosage
Medically reviewed by Drugs.com. Last updated on Sep 17, 2024.
Applies to the following strengths: 180 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Heterozygous Familial Hypercholesterolemia
180 mg orally once a day
Comments:
- This drug should be given with maximally tolerated statin therapy.
- Lipid levels should be checked within 8 to 12 weeks of treatment initiation.
Uses: As an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in those requiring additional LDL-C lowering.
Usual Adult Dose for Cardiovascular Risk Reduction
180 mg orally once a day
Comments:
- This drug should be given with maximally tolerated statin therapy.
- Lipid levels should be checked within 8 to 12 weeks of treatment initiation.
Uses: As an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in those requiring additional LDL-C lowering.
Renal Dose Adjustments
Mild to moderate renal impairment (eGFR 30 mL/min/1.73 m2 or greater): No adjustment recommended
Severe renal impairment (eGFR less than 30 mL/min/1.73 m2): Use caution as there is limited experience
Liver Dose Adjustments
Mild to moderate hepatic impairment (Child Pugh A or B): No adjustment recommended
Severe hepatic impairment: Data not available
Precautions
CONTRAINDICATIONS: None
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Take orally once a day with or without food
General:
- This drug, in combination with maximally tolerated statins (with or without other lipid modifying agents) decreases LDL-C, non-high-density lipoprotein cholesterol, apolipoprotein B, and total cholesterol.
- Concomitant use with simvastatin or pravastatin my increase the risk of simvastatin or pravastatin associated myopathy as it may increase the serum concentrations of these drugs.
Monitoring:
- Lipid levels should be checked within 8 to 12 weeks of therapy initiation
- Serum uric acid levels should be obtained as clinically indicated
Patient advice:
- Patients should be instructed to read the US FDA-approved patient labeling (Patient Information).
- Patients should be instructed to report tendinitis or tendon rupture symptoms.
- Patients should be instructed to report signs or symptoms of hyperuricemia.
- Patients should be instructed to speak with their healthcare provider if they are or are planning to become pregnant or breastfeeding.
More about bempedoic acid
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Further information
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