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Azilsartan medoxomil / chlorthalidone Side Effects

For the Consumer

Applies to azilsartan medoxomil / chlorthalidone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by azilsartan medoxomil / chlorthalidone. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking azilsartan medoxomil / chlorthalidone:

Less common:
  • Blurred vision
  • confusion
  • convulsions
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
Incidence not known:
  • Ankle, knee, or great toe joint pain
  • joint stiffness or swelling
  • lower back, side, or stomach pain
  • swelling of the feet or lower legs

Minor Side Effects

Some of the side effects that can occur with azilsartan medoxomil / chlorthalidone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Dizziness
  • Cough
  • diarrhea
  • lack or loss of strength
  • muscle spasm
Incidence not known:
  • Headache
  • loss of appetite
  • rash
  • stomach cramps

For Healthcare Professionals

Applies to azilsartan medoxomil / chlorthalidone: oral tablet


The most common side effects were dizziness and fatigue.[Ref]

Nervous system

Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Syncope
Postmarketing reports: Loss of consciousness

Common (1% to 10%): Dizziness
Frequency not reported: Dizziness postural

Common (1% to 10%): Dizziness
Frequency not reported: Headache[Ref]


Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Fatigue
Frequency not reported: Asthenia

Common (1% to 10%): Fatigue[Ref]


Common (1% to 10%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal

Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal

Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal[Ref]


Postmarketing reports: Nausea

Frequency not reported: Diarrhea, nausea

Frequency not reported: Gastrointestinal upset[Ref]


Common (1% to 10%): Hypotension[Ref]


Postmarketing reports: Rash, pruritus, angioedema

Frequency not reported: Rash[Ref]


Frequency not reported: Cholesterol elevated[Ref]


Frequency not reported: BUN increased

Frequency not reported: Uric acid elevated[Ref]


Frequency not reported: Muscle spasm[Ref]


Frequency not reported: Cough[Ref]


1. "Product Information. Edarbyclor (azilsartan-chlorthalidone)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Not all side effects for azilsartan medoxomil / chlorthalidone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.