Azilsartan Medoxomil / Chlorthalidone Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 1, 2024.

Applies to azilsartan medoxomil / chlorthalidone: oral tablet.

Important Warnings This medicine can cause some serious health issues

Oral route (Tablet)

Discontinue use of azilsartan medoxomil/chlorthalidone as quickly as possible if pregnancy is detected, as drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Other side effects

Some side effects of azilsartan medoxomil / chlorthalidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• dizziness

Rare

• cough
• diarrhea
• lack or loss of strength
• muscle spasm

Incidence not known

• headache
• loss of appetite
• rash
• stomach cramps

Serious side effects

Along with its needed effects, azilsartan medoxomil / chlorthalidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking azilsartan medoxomil / chlorthalidone:

Less common

• blurred vision
• confusion
• convulsions
• decreased urine
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fainting
• increased thirst
• irregular heartbeat
• loss of appetite
• muscle pain or cramps
• nausea or vomiting
• numbness or tingling in the hands, feet, or lips
• shortness of breath
• sweating
• unusual tiredness or weakness

Incidence not known

• ankle, knee, or great toe joint pain
• joint stiffness or swelling
• lower back, side, or stomach pain
• swelling of the feet or lower legs

For Healthcare Professionals

Applies to azilsartan medoxomil / chlorthalidone: oral tablet.

General

The most common side effects were dizziness and fatigue.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness
• Uncommon (0.1% to 1%): Syncope
• Postmarketing reports: Loss of consciousness
• Azilsartan:
• Common (1% to 10%): Dizziness
• Frequency not reported: Dizziness postural
• Chlorthalidone:
• Common (1% to 10%): Dizziness
• Frequency not reported: Headache^[Ref]

Other

• Common (1% to 10%): Fatigue
• Azilsartan:
• Uncommon (0.1% to 1%): Fatigue
• Frequency not reported: Asthenia
• Chlorthalidone:
• Common (1% to 10%): Fatigue^[Ref]

Renal

• Common (1% to 10%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal
• Azilsartan:
• Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal
• Chlorthalidone:
• Uncommon (0.1% to 1%): Consecutive creatinine increases of 50% or greater from baseline and greater than the upper limit of normal^[Ref]

Gastrointestinal

• Postmarketing reports: Nausea
• Azilsartan:
• Frequency not reported: Diarrhea, nausea
• Chlorthalidone:
• Frequency not reported: Gastrointestinal upset^[Ref]

Cardiovascular

• Common (1% to 10%): Hypotension^[Ref]

Dermatologic

• Postmarketing reports: Rash, pruritus, angioedema
• Chlorthalidone:
• Frequency not reported: Rash^[Ref]

Hepatic

Chlorthalidone:

Frequency not reported: Cholesterol elevated^[Ref]

Metabolic

• Frequency not reported: BUN increased
• Chlorthalidone:
• Frequency not reported: Uric acid elevated^[Ref]

Musculoskeletal

Azilsartan:

Frequency not reported: Muscle spasm^[Ref]

Respiratory

Azilsartan:

Frequency not reported: Cough^[Ref]

Further information

Azilsartan medoxomil/chlorthalidone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer