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Atropine / diphenoxylate Side Effects

Medically reviewed by Last updated on Apr 16, 2023.

Applies to atropine / diphenoxylate: oral solution, oral tablet.

Serious side effects

Along with its needed effects, atropine / diphenoxylate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine / diphenoxylate:

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking atropine / diphenoxylate:

Symptoms of overdose

For Healthcare Professionals

Applies to atropine / diphenoxylate: oral liquid, oral tablet.

Nervous system

Frequency not reported: Numbness of extremities, sedation/drowsiness, dizziness, headache, somnolence[Ref]


Frequency not reported: Swelling of the gums, toxic megacolon, paralytic ileus, pancreatitis, vomiting, nausea, abdominal discomfort, constipation[Ref]


Frequency not reported: Tachycardia, cardiac irregularities (e.g. arrhythmias, bradycardia, palpitations)[Ref]


Frequency not reported: Increased intraocular pressure, dilation of pupils with loss of accommodation, photophobia, angle closure glaucoma[Ref]


Frequency not reported: Urinary retention, difficulty in micturition[Ref]


Frequency not reported: Euphoria, depression, confusion, restlessness, hallucinations[Ref]


Frequency not reported: Urticaria, pruritus, flushing[Ref]


Frequency not reported: Anaphylaxis, angioneurotic edema[Ref]


Frequency not reported: Anorexia[Ref]


Frequency not reported: Respiratory depression in children[Ref]


Frequency not reported: Malaise/lethargy, hyperthermia, dryness of the skin and mucous membranes[Ref]


1. Product Information. Lomotil (atropine-diphenoxylate). Searle. PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.