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Atropine / Diphenoxylate Dosage

Applies to the following strength(s): 0.025 mg-2.5 mg ; 0.025 mg-2.5 mg/5 mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Diarrhea

Initial dose: 2 tablets or 10 mL (5 mg of diphenoxylate), orally, 4 times a day
Maintenance dose: Once control is achieved, reduce dose to individual requirements, to as little as 2 tablets or 10 mL once a day
Maximum dose: 20 mg diphenoxylate per day

Comments:
-Clinical improvement is usually seen within 48 hours.
-If no improvement is seen within 10 days, symptoms are unlikely to respond to further administration.

Usual Pediatric Dose for Diarrhea

2 years and older:
Initial dose: 0.3 to 0.4 mg/kg of diphenoxylate, orally, in 4 divided doses
Maintenance dose: Once control is achieved, reduce dose to individual requirements, to as little as one quarter of the initial daily dosage
Maximum dose: 20 mg diphenoxylate per day

Comments:
-These doses are approximate; adjust downward according to nutritional status and degree of dehydration.
-Reduce dose as soon as initial control of symptoms has been achieved.
-If no response within 48 hours, this medicine is unlikely to be effective.
-Use only the liquid medication in children under 13 years old; do not use tablets.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:
-Do not exceed the recommended dosage.
-Keep out of reach of children and in a child resistant container.
-Overdosage may cause severe respiratory depression and coma, possibly leading to permanent brain damage or death.
-May cause drowsiness or dizziness; use caution regarding activities requiring mental alertness, such as driving or operating dangerous machinery.
-May potentiate the effects of alcohol, barbiturates, and tranquilizers.

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