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Ampyra Side Effects

Generic name: dalfampridine

Medically reviewed by Last updated on Apr 3, 2022.

Note: This document contains side effect information about dalfampridine. Some of the dosage forms listed on this page may not apply to the brand name Ampyra.


Common side effects of Ampyra include: urinary tract infection. Other side effects include: balance impairment, insomnia, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dalfampridine: oral tablet extended release

Side effects requiring immediate medical attention

Along with its needed effects, dalfampridine (the active ingredient contained in Ampyra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:

More common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain

Less common

  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficulty controlling your bladder or bowels
  • feeling sad or depressed
  • forgetful
  • muscle cramps
  • problems with swallowing
  • slurred speech
  • unusual tiredness or weakness

Incidence not known

  • Chest tightness
  • cough
  • dizziness or lightheadedness
  • fast heartbeat
  • feeling of constant movement of self or surroundings
  • hives, itching, skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sensation of spinning
  • vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:

Symptoms of overdose

Side effects not requiring immediate medical attention

Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • lack or loss of strength
  • nausea
  • problems with balance
  • trouble sleeping

Less common

For Healthcare Professionals

Applies to dalfampridine: oral tablet extended release

Nervous system

Common (1% to 10%): Dizziness, headache, balance disorder, multiple sclerosis relapse, paresthesia, tremor

Uncommon (0.1% to 1%): Seizure, exacerbation of trigeminal neuralgia[Ref]


Common (1% to 10%): Nausea, constipation, dyspepsia

Postmarketing reports: Vomiting[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Nasopharyngitis, pharyngolaryngeal pain, dyspnea[Ref]


Very common (10% or more): Urinary tract infection (12%)[Ref]


Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity[Ref]


Common (1% to 10%): Insomnia, anxiety[Ref]


Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Chest discomfort[Ref]


Common (1% to 10%): Palpitations[Ref]


Uncommon (0.1% to 1%): Rash, urticaria[Ref]


1. "Product Information. Ampyra (dalfampridine)." Acorda Therapeutics (2010):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.