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Ampyra Side Effects

Generic name: dalfampridine

Medically reviewed by Last updated on Mar 13, 2024.

Note: This document contains side effect information about dalfampridine. Some dosage forms listed on this page may not apply to the brand name Ampyra.

Applies to dalfampridine: oral tablet extended release.

Serious side effects of Ampyra

Along with its needed effects, dalfampridine (the active ingredient contained in Ampyra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:

Symptoms of overdose

Other side effects of Ampyra

Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to dalfampridine: oral tablet extended release.

Nervous system

Common (1% to 10%): Dizziness, headache, balance disorder, multiple sclerosis relapse, paresthesia, tremor

Uncommon (0.1% to 1%): Seizure, exacerbation of trigeminal neuralgia[Ref]


Common (1% to 10%): Nausea, constipation, dyspepsia

Postmarketing reports: Vomiting[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Nasopharyngitis, pharyngolaryngeal pain, dyspnea[Ref]


Very common (10% or more): Urinary tract infection (12%)[Ref]


Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity[Ref]


Common (1% to 10%): Insomnia, anxiety[Ref]


Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Chest discomfort[Ref]


Common (1% to 10%): Palpitations[Ref]


Uncommon (0.1% to 1%): Rash, urticaria[Ref]


1. (2010) "Product Information. Ampyra (dalfampridine)." Acorda Therapeutics

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.