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Amiloride / hydrochlorothiazide Side Effects

For the Consumer

Applies to amiloride / hydrochlorothiazide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by amiloride / hydrochlorothiazide. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking amiloride / hydrochlorothiazide:

More common:
  • Abdominal pain
  • confusion
  • difficulty breathing
  • irregular heartbeats
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • weakness or heaviness of the legs
Less common:
  • Dizziness
  • fainting
  • fast or slow heartbeat
  • labored breathing
  • tightness in the chest
  • wheezing
  • Ankle, knee, or great toe joint pain
  • arm, back, or jaw pain
  • blistering, peeling, or loosening of the skin
  • bloody or black, tarry stools
  • bloody urine
  • burning while urinating
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain, discomfort, or heaviness
  • chills
  • cloudy urine
  • cold sweats
  • coma
  • constipation
  • convulsions
  • cough
  • cracks in the skin
  • decreased awareness or responsiveness
  • decreased frequency or amount of urine
  • diarrhea
  • difficult or painful urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • dry mouth
  • fever
  • headache
  • increase in heart rate
  • increased blood pressure
  • increased thirst
  • itching
  • joint pain, stiffness, or swelling
  • lightheadedness
  • loss of appetite
  • loss of heat from the body
  • lower back or side pain
  • muscle pain or cramps
  • pounding heartbeat or pulse
  • rapid breathing
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • severe sleepiness
  • severe stomach pain
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sunken eyes
  • sweating
  • swelling of the face, ankles, hands, fingers, or lower legs
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain
  • wrinkled skin

If any of the following symptoms of overdose occur while taking amiloride / hydrochlorothiazide, get emergency help immediately:

Symptoms of overdose:
  • Drowsiness
  • irritability
  • mood changes
  • pain or weakness in the hands or feet
  • trembling
  • weak pulse

Minor Side Effects

Some of the side effects that can occur with amiloride / hydrochlorothiazide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Rash
  • weight loss
Less common:
  • Leg ache
  • stomach pain
  • Bad taste
  • bloated, full feeling
  • blurred or loss of vision
  • changes in appetite
  • decreased interest in sexual intercourse
  • discouragement
  • disturbed color perception
  • double vision
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • feeling sad or empty
  • general feeling of discomfort or illness
  • hair loss or thinning of hair
  • hiccups
  • inability to have or keep an erection
  • increased sweating
  • increased urge to urinate during the night
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • loss of bladder control
  • loss of interest or pleasure
  • muscle spasm
  • night blindness
  • overbright appearance of lights
  • passing of gas
  • redness of the face, neck, arms, and occasionally upper chest
  • seeing halos around lights
  • sensation of spinning
  • sleepiness
  • sleeplessness
  • stomach fullness or discomfort
  • stuffy nose
  • swelling of the breasts or breast soreness in both females and males
  • trouble concentrating
  • trouble sleeping
  • tunnel vision
  • unable to sleep
  • waking to urinate at night

For Healthcare Professionals

Applies to amiloride / hydrochlorothiazide: oral tablet


The most common adverse reactions were headache, weakness, nausea/anorexia, dizziness, and rash.[Ref]


Common (1% to 10%): Nausea/anorexia, diarrhea, gastrointestinal pain, abdominal pain
Frequency not reported: Constipation, gastrointestinal bleeding, gastrointestinal disturbance, abdominal fullness, vomiting, flatulence

Frequency not reported: Activation of probable preexisting peptic ulcer, dyspepsia, heartburn, dry mouth

Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation[Ref]


Common (1% to 10%): Rash, pruritus
Frequency not reported: Diaphoresis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia

Frequency not reported: Alopecia, itching, diaphoresis

Frequency not reported: Cutaneous vasculitis, photosensitivity, urticaria, purpura, toxic epidermal necrolysis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Frequency not reported: Syncope, paresthesia/numbness, vertigo, stupor, sleepiness, bad taste

Frequency not reported: Encephalopathy, tremors, tinnitus, somnolence[Ref]


Common (1% to 10%): Weakness, fatigue/tiredness
Frequency not reported: Malaise, chest pain, digitalis toxicity, gynecomastia

Frequency not reported: Fatigability

Frequency not reported: Fever[Ref]


Common (1% to 10%): Serum potassium greater than 5.5 mEq/L
Frequency not reported: Appetite changes, anorexia, thirst, gout, dehydration, symptomatic hyponatremia, electrolyte imbalance, hyponatremia

Frequency not reported: Electrolyte imbalance, hyperglycemia, hyperuricemia, hypokalemia[Ref]


Common (1% to 10%): Arrhythmia
Frequency not reported: Tachycardia, orthostatic hypotension, angina pectoris, flushing

Frequency not reported: Palpitation, partial heart block increased to complete heart block

Frequency not reported: Vasculitis[Ref]


Common (1% to 10%): Leg ache
Frequency not reported: Back pain, muscle cramps/spasm, joint pain

Frequency not reported: Painful extremities, neck/shoulder ache[Ref]


Common (1% to 10%): Dyspnea
Frequency not reported: Hiccups, nasal congestion

Frequency not reported: Shortness of breath, cough

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Frequency not reported: Impotence, nocturia, dysuria, incontinence

Frequency not reported: Bladder spasm, polyuria, urinary frequency

Frequency not reported: Glycosuria[Ref]


Frequency not reported: Insomnia, nervousness, depression, mental confusion

Frequency not reported: Libido decreased

Frequency not reported: Restlessness[Ref]


Frequency not reported: Renal dysfunction, renal failure

Frequency not reported: Interstitial nephritis[Ref]


Frequency not reported: Visual disturbance

Frequency not reported: Intraocular pressure increased

Frequency not reported: Transient blurred vision, xanthopsia[Ref]


Frequency not reported: Anaphylactic reaction

Frequency not reported: Anaphylactic reaction[Ref]


Frequency not reported: Aplastic anemia, neutropenia

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia[Ref]


Frequency not reported: Abnormal liver function, jaundice

Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Moduretic (amiloride-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for amiloride / hydrochlorothiazide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.