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Allopurinol / lesinurad Side Effects

Medically reviewed by Last updated on Aug 27, 2022.

Applies to allopurinol/lesinurad: oral tablet.


  • Kidney problems like kidney failure have happened with this drug. Tell your doctor if you have ever had kidney problems.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Upset stomach or throwing up.
  • Lower back or side pain.
  • Pain when passing urine.
  • Swollen gland.
  • Joint pain.
  • Seizures.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to allopurinol / lesinurad: oral tablet.


The most commonly reported side effects included increased blood/serum creatinine, influenza, and headache.[Ref]


Very common (10% or more): Blood creatinine increased (up to 11.4%), serum creatinine elevation 1.5 to less than 2 times baseline (up to 11%)

Common (1% to 10%): nephrolithiasis, renal failure, serum creatinine elevation greater than or equal to 2 times baseline

Frequency not reported: Acute prerenal/renal failure, acute uric acid nephropathy, chronic renal failure, renal events, renal impairment


Postmarketing reports: Azotemia, nephritis, renal failure


Frequency not reported: Kidney stones, renal-related adverse reactions, transient serum creatinine increases[Ref]

Renal failure and blood creatinine increased more commonly occurred in patients with reduced kidney function (e.g., CrCl 30 to 60 mL/min).[Ref]

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Drowsiness, non-fatal stroke


Postmarketing reports: Ageusia/taste loss, amnesia, dizziness, headache, neuritis, paresthesia, peripheral neuropathy, peroneal nerve palsy, somnolence, vertigo[Ref]


Common (1% to 10%): Gastroesophageal reflux disease


Postmarketing reports: Abdominal pain, dyspepsia, gastritis, gastrointestinal hemorrhage, hemorrhagic pancreatitis, salivary gland enlargement, stomatitis, tongue edema, vomiting[Ref]


Common (1% to 10%): Influenza[Ref]


Frequency not reported: Cardiovascular death, cardiovascular events/major adverse cardiovascular events (MACE), non-fatal myocardial infarction


Postmarketing reports: Bradycardia, necrotizing vasculitis, pericarditis, peripheral vascular disorder, thrombophlebitis, vasculitis, vasodilation


Frequency not reported: Cardiovascular death, MACE, non-fatal myocardial infarction[Ref]

There were 1.85 major adverse cardiovascular events (MACE) per 100 patient-years of exposure for the combination drug, while there were 0.61 events for lesinurad and 0.6 events for placebo.[Ref]


Frequency not reported: Skin rash


Postmarketing reports: Alopecia, bullous dermatitis, ecchymosis, eczema, erythema multiforme, exfoliative dermatitis, face edema, furuncle, hyperhidrosis, leukocytoclastic vasculitis, lichen planus, onycholysis, pruritus, skin edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria[Ref]


Frequency not reported: Bone marrow depression


Postmarketing reports: Agranulocytosis, anemia, aplastic anemia, eosinophilia, hemolytic anemia, leukocytosis, leukopenia, lymphadenopathy, lymphocytosis, pancytopenia, prothrombin level decreased, purpura, reticulocytosis, thrombocytopenia[Ref]


Frequency not reported: Hypersensitivity[Ref]



Postmarketing reports: Amblyopia, cataract, conjunctivitis, iritis, optic neuritis, retinitis[Ref]



Postmarketing reports: Confusional state, depression, insomnia, libido decreased[Ref]



Postmarketing reports: Asthenia, malaise, pyrexia, tinnitus[Ref]



Postmarketing reports: Albuminuria, erectile dysfunction, hematuria, infertility male[Ref]



Postmarketing reports: Decreased appetite, hypercalcemia, hyperlipidemia[Ref]



Postmarketing reports: Asthma, bronchospasm, epistaxis, pharyngitis, rhinitis[Ref]



Postmarketing reports: Arthralgia, myalgia[Ref]



Postmarketing reports: Gynecomastia[Ref]


Frequency not reported: Hepatotoxicity


Postmarketing reports: Cholestatic jaundice, granulomatous hepatitis, hepatic necrosis, hepatitis, hepatomegaly, hyperbilirubinemia[Ref]

More about allopurinol / lesinurad

Patient resources

Other brands


Related treatment guides


1. "Product Information. Duzallo (allopurinol-lesinurad)." Ironwood Pharmaceuticals, Inc (2017):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.