Skip to Content
Is your RA under control? Take an assessment here >

Febuxostat

Generic Name: febuxostat (fe BUX oh stat)
Brand Name: Uloric

Medically reviewed on April 24, 2018

What is febuxostat?

Febuxostat reduces the production of uric acid in your body. A build-up of uric acid can cause gout symptoms.

Febuxostat is used to keep uric acid levels from getting to high in people with gout.

Febuxostat may also be used for purposes not listed in this medication guide.

Important Information

You should not use febuxostat if you also use azathioprine or mercaptopurine.

Before taking this medicine

You should not use febuxostat if you are allergic to it, or if you also use:

  • azathioprine; or

  • mercaptopurine.

Tell your doctor if you have ever had:

  • liver or kidney disease;

  • heart disease;

  • a heart attack or stroke;

  • cancer;

  • Lesch-Nyhan syndrome; or

  • an organ transplant (kidney, liver, lung, heart).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I take febuxostat?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take febuxostat with or without food. Febuxostat may be taken with an antacid if needed.

You may have an increase in gout symptoms (flares) when you first start taking febuxostat. Your doctor may prescribe other medications for you to use during the first 6 months of treatment with febuxostat.

For best results, keep using your medications as directed. Call your doctor if your symptoms do not improve after 6 months, or if they get worse.

You will need frequent blood tests to check your liver function.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking febuxostat?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Febuxostat side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • liver problems--stomach pain (upper right side), unusual tiredness, dark urine, jaundice (yellowing of the skin or eyes); or

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects may include:

  • gout flares, joint pain;

  • nausea;

  • mild rash; or

  • liver problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Febuxostat dosing information

Usual Adult Dose for Gout:

Initial dose: 40 mg orally once a day
-If serum uric acid level is greater than 6 mg/dL after 2 weeks, increase the dose to 80 mg orally once a day
Maintenance dose: 40 to 80 mg orally once a day

Comments:
-Use of this drug should occur after an acute gout flare subsides.
-Gout flares may occur due to increased urate mobilization from tissue deposits, especially during initiation; gout flare prophylaxis with a non-steroidal anti-inflammatory or colchicine is recommended and may be beneficial for up to 6 months.
-Uric acid levels may be checked as soon as 2 weeks after beginning this drug.

Use: Chronic management of symptomatic hyperuricemia in patients with gout

What other drugs will affect febuxostat?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect febuxostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide