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Febuxostat Dosage

Medically reviewed by Last updated on Feb 15, 2024.

Applies to the following strengths: 40 mg; 80 mg

Usual Adult Dose for Gout

Initial dose: 40 mg orally once a day

Maintenance dose: 40 to 80 mg orally once a day
Maximum dose: 80 mg/day


Use: For the chronic management of hyperuricemia in patients with gout who have an inadequate experience to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable.

Renal Dose Adjustments

Mild to Moderate Renal Dysfunction: No adjustment recommended
Severe Renal Dysfunction (CrCl 15 to less than 30 mL/min): Maximum daily dose should be limited to 40 mg/day
ESRD (CrCl less than 15 mL/min): Data not available

Liver Dose Adjustments

Mild to Moderate Liver Dysfunction (Child-Pugh Class A and B): No adjustment recommended
Severe Liver Dysfunction (Child-Pugh Class C): Use with caution

Dose Adjustments

Therapeutic target is to decrease and maintain serum uric acid levels below 6 mg/dL

Concomitant use with mercaptopurine/azathioprine is contraindicated




Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.