Lesinurad and Allopurinol

Generic name: Lesinurad and Allopurinol [ le-SIN-ure-ad-& al-oh-PURE-i-nole ]
Brand name: Duzallo
Drug class: Antihyperuricemic agents

Medically reviewed by Drugs.com. Last updated on Oct 2, 2023.

Uses of Lesinurad and Allopurinol:

• It is used to lower uric acid in the blood.

What do I need to tell my doctor BEFORE I take Lesinurad and Allopurinol?

• If you are allergic to lesinurad and allopurinol; any part of lesinurad and allopurinol; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have kidney disease or are on dialysis.
• If you have had a kidney transplant.
• If you have liver disease.
• If you have any of these health problems: Lesch-Nyhan syndrome or tumor lysis syndrome (TLS).
• If you are taking any of these drugs: Divalproex or valproic acid.
• If you are taking another drug that has the same drug in it.

This is not a list of all drugs or health problems that interact with lesinurad and allopurinol.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take lesinurad and allopurinol with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Lesinurad and Allopurinol?

• Tell all of your health care providers that you take lesinurad and allopurinol. This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how lesinurad and allopurinol affects you.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• The chance of gout attacks may be higher for a few months after you start taking lesinurad and allopurinol. Do not stop taking lesinurad and allopurinol. You may be given other drugs to help you keep from getting gout attacks. Talk with your doctor.
• Low blood cell counts have happened with allopurinol. Most people were also taking drugs that could cause low blood cell counts. If blood cell counts get very low, this can lead to bleeding problems and infection. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.
• Very bad heart problems like heart attack and stroke have happened with lesinurad and allopurinol. Sometimes, these heart problems were deadly. It is not known if lesinurad and allopurinol is what caused these effects. Talk with the doctor.
• Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking lesinurad and allopurinol.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using lesinurad and allopurinol while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Lesinurad and Allopurinol) best taken?

Use lesinurad and allopurinol as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take in the morning.
• Take with food.
• Take with a full glass of water.
• Drink lots of noncaffeine liquids every day unless told to drink less liquid by your doctor.
• Keep taking lesinurad and allopurinol even if you are having a gout attack.
• Keep taking lesinurad and allopurinol as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

• Skip the missed dose and go back to your normal time.
• Do not take more than 1 dose of lesinurad and allopurinol in the same day.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Upset stomach or throwing up.
• Lower back or side pain.
• Pain when passing urine.
• Swollen gland.
• Joint pain.
• Seizures.
• A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Related/similar drugs

What are some other side effects of Lesinurad and Allopurinol?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache.
• Flu-like signs.
• Heartburn.
• Diarrhea.
• Upset stomach.
• Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Lesinurad and Allopurinol?

• Store at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about lesinurad and allopurinol, please talk with your doctor, nurse, pharmacist, or other health care provider.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time lesinurad and allopurinol is refilled. If you have any questions about lesinurad and allopurinol, please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer