Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels Side Effects
Generic name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine
Medically reviewed by Drugs.com. Last updated on Apr 5, 2023.
Note: This document contains side effect information about acetaminophen / dextromethorphan / guaifenesin / phenylephrine. Some dosage forms listed on this page may not apply to the brand name Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels.
Applies to acetaminophen / dextromethorphan / guaifenesin / phenylephrine: oral capsule, oral liquid, oral tablet.
Serious side effects
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Not able to pass urine or change in how much urine is passed.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
Other side effects
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling nervous and excitable.
- Not able to sleep.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to acetaminophen/dextromethorphan/guaifenesin/phenylephrine: oral capsule, oral liquid, oral powder for reconstitution, oral tablet.
The manufacturer has not provided adverse event information.[Ref]
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1. "Product Information. Tylenol Cold and Flu Severe (acetaminophen/dextromethorphan/guaifenesin/PE)." Johnson and Johnson/McNeil Consumer (2022):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.