Skip to main content

Aldara Side Effects

Generic name: imiquimod topical

Medically reviewed by Drugs.com. Last updated on Aug 8, 2024.

Note: This document provides detailed information about Aldara Side Effects associated with imiquimod topical. Some dosage forms listed on this page may not apply specifically to the brand name Aldara.

Applies to imiquimod topical: topical cream.

Serious side effects of Aldara

Along with its needed effects, imiquimod topical (the active ingredient contained in Aldara) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking imiquimod topical:

More common side effects

  • blisters on the skin
  • body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • itching in the genital or other skin areas
  • loss of voice
  • open sores or scabs on the skin
  • pain or tenderness around the eyes and cheekbones
  • redness of the skin (severe)
  • scaling
  • shortness of breath or troubled breathing
  • skin rash
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest or wheezing
  • unusual tiredness or weakness

Less common side effects

  • abdominal or stomach pain
  • ankle, knee, or great toe joint pain
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chest pain
  • cold flu-like symptoms
  • difficult, burning, or painful urination
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • frequent urge to urinate
  • hoarseness
  • joint stiffness or swelling
  • lower back or side pain
  • lump in the abdomen or stomach
  • nervousness
  • persistent non-healing sore
  • pink growth on the skin
  • pounding in the ears
  • reddish patch or irritated area
  • severe headache
  • shiny bump on the skin
  • slow or fast heartbeat
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • white, yellow or waxy scar-like area

Incidence not known

  • blue lips and fingernails
  • convulsions
  • coughing that sometimes produces a pink frothy sputum
  • dilated neck veins
  • extreme fatigue
  • fast, irregular, or pounding heartbeat
  • headache
  • irregular breathing
  • nausea or vomiting
  • pain in the shoulders, arms, jaw, or neck
  • slurred speech
  • sudden and severe inability to speak
  • suicide
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • temporary blindness
  • weakness in the arm or leg on one side of the body
  • weight gain

Get emergency help immediately if any of the following symptoms of overdose occur while taking imiquimod topical:

Symptoms of overdose

Other side effects of Aldara

Some side effects of imiquimod topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • burning or stinging of the skin (mild)
  • flaking of the skin
  • mild headache
  • pain, soreness, or tenderness of the skin (mild)
  • rash
  • redness of the skin (mild)
  • swelling at place of application

Less common side effects

For healthcare professionals

Applies to imiquimod topical: topical cream.

General adverse events

The most frequently reported side effects are local skin reactions (e.g., erythema, edema, weeping/exudate, flaking/scaling/dryness, scabbing/crusting, and erosion/ulceration), headache, application site reactions, influenza-like illness, fatigue, nausea, and fever.[Ref]

Local

Respiratory

Immunologic

Nervous system

Other

Gastrointestinal

Oncologic

Hematologic

Cardiovascular

Dermatologic

Musculoskeletal

Genitourinary

Psychiatric

Ocular

Metabolic

Hepatic

Endocrine

References

1. (2001) "Product Information. Aldara (imiquimod topical)." 3M Pharmaceuticals

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

4. (2017) "Product Information. Zyclara (imiquimod topical)." Medicis Pharmaceutical Corporation

Frequently asked questions

Further information

Aldara side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.