Generic Name: vismodegib (VIS moe DEG ib)
Brand Names: Erivedge
Medically reviewed by P. Thornton, DipPharm Last updated on May 3, 2019.
What is Erivedge?
Erivedge (vismodegib) is a cancer medicine that interferes with the growth of certain cancer cells in the body.
Erivedge is used to treat basal cell carcinoma that has spread to other parts of the body.
Erivedge may also be used for purposes not listed in this medication guide.
Do not use Erivedge if you are pregnant, or if you are a man and your sexual partner is pregnant. Erivedge use by either parent may cause severe birth defects or death of a baby.
For Women: Use effective birth control to prevent pregnancy while you are using this medicine and for at least 24 months after your last dose. Call your doctor at once if you quit using birth control, if your period is late, or if you think you might be pregnant.
For Men: Always use a latex condom and spermicide when having sex, even if you have had a vasectomy. Continue using condoms and spermicide for at least 3 months after you stop taking Erivedge.
Call your doctor at once if a pregnancy occurs while either sexual partner is taking vismodegib.
Before taking this medicine
You should not use Erivedge if you are allergic to vismodegib, or:
if you are pregnant or breast-feeding.
You will need to have a negative pregnancy test within 7 days before you start taking Erivedge.
You must prevent pregnancy while you are taking Erivedge, whether you are a man or a woman. Vismodegib can cause severe birth defects or death of a baby.
For Women: Use effective birth control while taking Erivedge and for 7 months after your last dose. The birth control method you use must be proven highly effective (at least 99%), such as: hormonal birth control (pills, vaginal ring, implants, or injections), an intrauterine device (IUD), or a tubal ligation. Call your doctor at once if you quit using birth control, if your period is late, or if you think you might be pregnant.
If you become pregnant, your name may be listed on a pregnancy registry to track the effects of vismodegib on the baby.
For Men: While you are taking Erivedge you must not have unprotected sex with a pregnant woman, or cause a woman to become pregnant. Vismodegib can affect your sperm and may cause harm to the baby at conception or during pregnancy. Always use a latex condom and spermicide when having sex, even if you have had a vasectomy. Continue using condoms and spermicide for at 3 months after you stop taking vismodegib.
Call your doctor at once if a pregnancy occurs while either the mother or the father is taking vismodegib.
To make sure this medicine is safe for you, tell your doctor if you have:
liver disease; or
You should not breast-feed while you are using Erivedge and for 7 months after your last dose.
How should I take Erivedge?
Take Erivedge exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Erivedge is usually taken once per day. You may take the medicine with or without food.
Do not crush, chew, break, or open a capsule. Swallow the capsule whole.
Store at room temperature away from moisture and heat.
Erivedge dosing information
Usual Adult Dose for Basal Cell Carcinoma:
Usual adult dose: 150 mg orally once a day
Duration of therapy: Until disease progression or until unacceptable toxicity.
Use: Treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation.
What happens if I miss a dose?
Skip the missed dose and wait until your next scheduled dose to take the medication. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Erivedge?
Do not donate blood while taking Erivedge and for 7 months after your treatment ends.
Do not donate sperm (semen) while taking vismodegib and for 3 months after your treatment ends.
This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Erivedge side effects
Get emergency medical help if you have signs of an allergic reaction to Erivedge: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you miss a menstrual period. This could be a side effect, or it may be a sign that you are pregnant.
Common Erivedge side effects may include:
nausea, vomiting, decreased appetite;
joint pain, muscle spasms;
weight loss; or
decreased sense of taste.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Erivedge?
Other drugs may interact with vismodegib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Erivedge only for the indication prescribed.
Copyright 1996-2019 Cerner Multum, Inc. Version: 4.01.
More about Erivedge (vismodegib)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Pricing & Coupons
- En Español
- Drug class: hedgehog pathway inhibitors
- FDA Approval History