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Hedgehog pathway inhibitors

What are Hedgehog pathway inhibitors?

The Hedgehog pathway plays an essential role in cell growth and differentiation in the developing embryo. It is typically silenced in adult tissues. In postembryonic life, the pathway may be activated to stimulate tissue repair or cell proliferation. Abnormal activation may lead to cancer, including basal cell carcinoma. Hedgehog pathway inhibitors target the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors. Hedgehog pathway inhibitors may be used to treat basal cell carcinoma that has spread to other parts of the body.

List of Hedgehog pathway inhibitors:

View by  Brand | Generic
Drug Name Reviews Avg. Ratings
Erivedge (Pro)
Generic name: vismodegib
1 review
Odomzo (Pro)
Generic name: sonidegib
1 review
Daurismo (Pro)
Generic name: glasdegib
0 reviewsAdd rating
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

See Also

Medical conditions associated with hedgehog pathway inhibitors: