Erivedge Side Effects

Generic Name: vismodegib

Note: This page contains information about the side effects of vismodegib. Some of the dosage forms included on this document may not apply to the brand name Erivedge.

For the Consumer

Applies to vismodegib: oral capsule

In addition to its needed effects, some unwanted effects may be caused by vismodegib (the active ingredient contained in Erivedge). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking vismodegib:

• Bloody or cloudy urine
• coma
• confusion
• convulsions
• decreased urine output
• dizziness
• dry mouth
• fast or irregular heartbeat
• headache
• increased thirst
• muscle pain or cramps
• nausea or vomiting
• pain in the lower back or side
• shortness of breath
• swelling of the face, ankles, or hands
• thirst
• unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with vismodegib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

• Absent, missed, or irregular menstrual periods
• change in taste
• decreased appetite
• diarrhea
• difficulty having a bowel movement (stool)
• difficulty with moving
• hair loss or thinning of the hair
• loss of taste
• muscle spasm or stiffness
• pain in the joints
• stopping of menstrual bleeding
• weight loss

For Healthcare Professionals

Applies to vismodegib: oral capsule

Dermatologic

Very common (10% or more): Alopecia (63.8%), pruritus
Common (1% to 10%): Rash, madarosis, abnormal hair growth^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (30.4%), diarrhea (29.0%), constipation (21.0%), vomiting (13.8%)
Common (1% to 10%): Dyspepsia, upper abdominal pain, abdominal pain^[Ref]

General

The most frequent adverse drug reactions reported were muscle spasms (74.6%), alopecia (65.2%), dysgeusia (57.2%), weight loss (48.6%), fatigue (44.9%), and nausea (34.8%).^[Ref]

Genitourinary

Very common (10% or more): Amenorrhea^[Ref]

Metabolic

Very common (10% or more): Weight loss (44.9%), decreased appetite (25.4%)
Common (1% to 10%): Dehydration, hyponatremia, azotemia, and hypokalemia^[Ref]

Musculoskeletal

Very common (10% or more): Muscle spasms (71.7%), arthralgia (15.9%)
Common (1% to 10%): Pain in extremity, back pain, musculoskeletal chest pain, myalgia, flank pain, musculoskeletal pain^[Ref]

Nervous system

Very common (10% or more): Dysgeusia (55.1%), ageusia (10.9%)
Common (1% to 10%): Hypogeusia^[Ref]

Hepatic

Common (1% to 10%): Hepatic enzymes increased^[Ref]

Other

Very common (10% or more): Fatigue (39.9%)
Common (1% to 10%): Pain, asthenia^[Ref]

Renal

Common (1% to 10%): Elevated blood urea nitrogen^[Ref]

Not all side effects for Erivedge may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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