Akynzeo Side Effects

Generic name: netupitant / palonosetron

Medically reviewed by Drugs.com. Last updated on May 19, 2024.

Note: This document provides detailed information about Akynzeo Side Effects associated with netupitant / palonosetron. Some dosage forms listed on this page may not apply specifically to the brand name Akynzeo.

Applies to netupitant / palonosetron: oral capsule.

Precautions

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, a fast heartbeat, fever, hives, itching, irritation, hoarseness, joint pain, stiffness or swelling, rash, redness of the skin, swelling of the eyelids, face, lips, hands, or feet, tightness in the chest, or trouble breathing or swallowing after using this medicine.

This medicine may cause a serious condition called serotonin syndrome if taken together with some medicines such as fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), a MAO inhibitor (such as methylene blue injection, Eldepryl®, Marplan®, Nardil®, Parnate®), medicine to treat migraine headaches (such as tramadol, Ultram®), or medicine to treat depression (eg, fluoxetine, mirtazapine, paroxetine, Celexa®, Effexor®, Lexapro®, Paxil®, Zoloft®). Check with your doctor first before taking any other medicines with netupitant and palonosetron combination.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Akynzeo

Some side effects of netupitant / palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Akynzeo

Along with its needed effects, netupitant / palonosetron may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking netupitant / palonosetron:

For healthcare professionals

Applies to netupitant / palonosetron: oral capsule.

Gastrointestinal adverse events

• Common (1% to 10%): Constipation, dyspepsia
• Uncommon (0.1% to 1%): Abdominal distention, abdominal pain, diarrhea, flatulence, nausea
• Rare (0.01% to 0.1%): Dysphagia, tongue coated

Palonosetron:

• Common (1% to 10%): Constipation, dyspepsia^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Uncommon (0.1% to 1%): Dizziness, vertigo
• Rare (0.01% to 0.1%): Abnormal taste, hypoesthesia

Palonosetron:

• Common (1% to 10%): Headache^[Ref]

Dermatologic

• Common (1% to 10%): Erythema
• Uncommon (0.1% to 1%): Alopecia, urticaria

Palonosetron:

• Common (1% to 10%): Erythema^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Insomnia
• Rare (0.01% to 0.1%): Acute psychosis, altered mood, sleep disorder

Palonosetron:

• Common (1% to 10%): Asthenia, fatigue^[Ref]

Other

• Common (1% to 10%): Asthenia, fatigue
• Rare (0.01% to 0.1%): Feeling hot

Palonosetron:

• Uncommon (0.1% to 1%): Fatigue^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Atrioventricular (AV) block, AV block first degree, bundle branch block, cardiomyopathy, conduction disorder, electrocardiogram QT prolonged, hypertension
• Rare (0.01% to 0.1%): Arrhythmia, AV block second degree, electrocardiogram ST segment depression, electrocardiogram ST-T segment abnormal, hypotension, increased troponin, mitral valve incompetence, myocardial ischemia, ventricular extrasystoles

Palonosetron:

• Postmarketing reports: Shock^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Elevated ALT, elevated AST, elevated total bilirubin, increased blood alkaline phosphatase
• Rare (0.01% to 0.1%): Increased blood bilirubin

Palonosetron:

• Uncommon (0.1% to 1%): Elevated AST, elevated ALT, elevated total bilirubin^[Ref]

Approximately 0.6% of patients given 0.5 mg of palonosetron developed AST greater than 3 times the upper limit of normal (ULN) and/or ALT greater than 3 x ULN with total bilirubin greater than ULN. Approximately 0.2% of patients given the same dose of palonosetron developed AST greater than 10 x ULN and/or ALT greater than 10 x ULN with total bilirubin greater than ULN, and approximately 0.1% of patients developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN.

Approximately 0.3% of patients given oral formulations of netupitant-palonosetron developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than ULN, and AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN occurred in up to 0.1% of patients.^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Leukocytosis, neutropenia
• Rare (0.01% to 0.1%): Leukopenia, lymphocytosis^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Increased blood creatine phosphokinase
• Rare (0.01% to 0.1%): Back pain, non-cardiac chest pain

Palonosetron:

• Uncommon (0.1% to 1%): Myalgia^[Ref]

Ocular

• Rare (0.01% to 0.1%): Blurred vision, conjunctivitis

Palonosetron:

• Uncommon (0.1% to 1%): Eye swelling^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Decreased appetite
• Rare (0.01% to 0.1%): Hypokalemia^[Ref]

Renal

• Uncommon (0.1% to 1%): Increased blood creatinine
• Rare (0.01% to 0.1%): Cystitis^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Hiccups

Palonosetron:

• Frequency not reported: Dyspnea^[Ref]

Hypersensitivity

Palonosetron:

• Postmarketing reports: Anaphylactic/anaphylactoid reactions, anaphylaxis^[Ref]

See also:

Frequently asked questions

• What is the difference between the oral and injectable formulations of Akynzeo?

Further information

Akynzeo side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer