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Akynzeo Side Effects

Generic Name: netupitant / palonosetron

Note: This page contains information about the side effects of netupitant / palonosetron. Some of the dosage forms included on this document may not apply to the brand name Akynzeo.

For the Consumer

Applies to netupitant / palonosetron: oral capsule

In addition to its needed effects, some unwanted effects may be caused by netupitant / palonosetron. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking netupitant / palonosetron:

Incidence not known:
  • Agitation
  • confusion
  • dizziness
  • fever
  • hearing or seeing things that are not there
  • muscle twitching
  • overactive reflexes
  • poor coordination
  • shivering
  • sweating
  • trembling or shaking

Minor Side Effects

Some of the side effects that can occur with netupitant / palonosetron may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Headache
  • fatigue
  • unusual tiredness or weakness
Less common:
  • constipation
  • flushing or redness of the skin
  • heartburn
  • indigestion
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to netupitant / palonosetron: oral capsule


Common (1% to 10%): Erythema[Ref]


Common (1% to 10%): Dyspepsia, constipation[Ref]


AST greater than 3 times the upper limit of normal (ULN) and/or ALT greater than 3 x ULN with total bilirubin greater than ULN occurred in up to 0.3% of patients, and AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN occurred in up to 0.1% of patients.[Ref]

Uncommon (0.1% to 1%): Elevated AST, elevated ALT, elevated total bilirubin[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Common (1% to 10%): Fatigue, asthenia[Ref]


1. "Product Information. Akynzeo (netupitant-palonosetron)." Eisai Inc, Woodcliff Lake, NJ.

Not all side effects for Akynzeo may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.