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Palonosetron (injection)

Generic Name: palonosetron (injection) (PAL oh NOE se tron)
Brand Name: Aloxi

Medically reviewed by Drugs.com on Jun 19, 2018 – Written by Cerner Multum

What is palonosetron?

Palonosetron is used in adults to prevent nausea and vomiting caused by surgery, or by receiving medicine to treat cancer (chemotherapy).

Palonosetron is used in children as young as 1 month old only to prevent nausea and vomiting caused by cancer medicine.

Palonosetron may also be used for purposes not listed in this medication guide.

Important Information

Before you receive palonosetron, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding.

Before taking this medicine

You should not be treated with palonosetron if you are allergic to it.

Tell your doctor if you have ever had an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran).

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with palonosetron and cause a serious condition called serotonin syndrome.

Tell your doctor if you are pregnant or breast-feeding.

How is palonosetron given?

Palonosetron is given as an infusion into a vein. A healthcare provider will give you this injection.

Palonosetron is usually given 30 minutes before chemotherapy, or right before you are given anesthesia for surgery.

What happens if I miss a dose?

Because you will receive palonosetron in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since palonosetron is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving palonosetron?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Palonosetron side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Palonosetron dosing information

Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:

0.25 mg via IV infusion over 30 seconds ONCE 30 minutes before the start of chemotherapy

Comments:
-The infusion line should be flushed with normal saline prior to and after administration of this drug.
-This drug should not be mixed with other drugs.

Uses:
-Prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy
-Prevention of acute nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy

Usual Adult Dose for Nausea/Vomiting -- Postoperative:

0.075 mg via IV injection over 10 seconds ONCE immediately before induction of anesthesia

Comments:
-Efficacy beyond 24 hours has not been determined.
-Routine prophylaxis is not recommended in patients in whom there is little expectation of postoperative nausea/vomiting (PONV).
-Use is recommended in situations where nausea/vomiting must be avoided in the postoperative period, even when the incidence of PONV is low.

Use: Prevention of PONV for up to 24 hours following surgery

Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:

1 month to younger than 17 years: 20 mcg/kg via IV infusion over 15 seconds ONCE 30 minutes before the start of chemotherapy
-Maximum dose: 1.5 mg

17 years and older: 0.25 mg via IV infusion over 30 seconds ONCE 30 minutes before the start of chemotherapy

Comments:
-The infusion line should be flushed with normal saline prior to and after administration of this drug.
-This drug should not be mixed with other drugs.

Uses:
-Patients 1 month to younger than 17 years: Prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy
-Patients 17 years and older: Prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy
-Patients 17 years and older: Prevention of acute nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy

What other drugs will affect palonosetron?

Many drugs can affect palonosetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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