Generic Name: palonosetron (injection) (PAL oh NOE se tron)
Brand Name: Aloxi
Medically reviewed on May 7, 2018
What is palonosetron?
Palonosetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Palonosetron is used in children only to prevent nausea and vomiting caused by cancer medicine.
Palonosetron may also be used for purposes not listed in this medication guide.
Before you receive palonosetron, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding.
Before taking this medicine
You should not be treated with palonosetron if you are allergic to it.
Tell your doctor if you are pregnant.
You should not breast-feed while using palonosetron.
How is palonosetron given?
Palonosetron is given as an infusion into a vein. A healthcare provider will give you this injection.
Palonosetron is usually given 30 minutes before chemotherapy, or right before you are given anesthesia for surgery.
What happens if I miss a dose?
Because you will receive palonosetron in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Since palonosetron is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving palonosetron?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Palonosetron side effects
Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Palonosetron dosing information
Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:
Oral: 0.5 mg orally administered approximately 1 hour prior to the start of chemotherapy
Uses: Moderately emetogenic cancer chemotherapy: Prevention of acute nausea and vomiting associated with initial and repeat courses.
Parenteral: 0.25 mg IV as a single dose 30 minutes before the start of chemotherapy
Uses: Prevention of acute nausea and vomiting in adults associated with initial and repeat courses of moderately and highly emetogenic cancer chemotherapy.
Usual Adult Dose for Nausea/Vomiting -- Postoperative:
Parenteral: 0.075 mg IV as a single dose immediately before induction of anesthesia
Uses: Prevention of postoperative nausea and vomiting (PONV) in adults for up to 24 hours following surgery. Efficacy beyond 24 hours has not been determined.
Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:
Parenteral: 20 mcg/kg IV (maximum 1.5 mg x 1) infused over 15 minutes beginning 30 minutes before the start of chemotherapy
Uses: Prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy in patients 1 month to less than 17 years of age.
What other drugs will affect palonosetron?
Using palonosetron while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use:
medicine for depression or mental illness;
migraine headache medicine;
Parkinson's disease medication;
medicine to treat a serious infections;
opioid medication; or
other medicine to prevent nausea and vomiting.
This list is not complete and many other drugs may affect palonosetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 5.01.
More about palonosetron
- Palonosetron Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- 2 Reviews
- Drug class: 5HT3 receptor antagonists
Other brands: Aloxi
- Palonosetron Hydrochloride (AHFS Monograph)
- Palonosetron Hydrochloride Injection (FDA)
- Palonosetron (Wolters Kluwer)