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Adlyxin Side Effects

Generic name: lixisenatide

Medically reviewed by Drugs.com. Last updated on Aug 16, 2024.

Note: This document provides detailed information about Adlyxin.

Applies to lixisenatide: parenteral injection Side Effects associated with lixisenatide. Some dosage forms listed on this page may not apply specifically to the brand name Adlyxin.

Applies to lixisenatide: parenteral injection.

Side effects include:

Lixisenatide: Nausea, vomiting, headache, diarrhea, dizziness, hypoglycemia.

Fixed combination of insulin glargine and lixisenatide (the active ingredient contained in Adlyxin) Hypoglycemia, nausea, nasopharyngitis, diarrhea, upper respiratory tract infection, headache.

For healthcare professionals

Applies to lixisenatide: subcutaneous kit, subcutaneous solution.

General

The most frequently reported adverse reactions were nausea, vomiting, headache, diarrhea, dizziness, and hypoglycemia.[Ref]

Gastrointestinal

Gastrointestinal adverse reactions including nausea and vomiting were responsible for discontinuation of treatment in 4.3% of patients. During clinical trials, the severity of gastrointestinal adverse reactions were graded as mild, moderate or severe in 64.2%, 32.3%, and 3.5% of cases, respectively. The majority of reactions occurred during the first 3 weeks of treatment.

During clinical trials, 21 cases of pancreatitis were reported including acute pancreatitis (n=3), pancreatitis (n=12), chronic pancreatitis (n=5), and edematous pancreatitis (n=1). Of these cases, some had risk factors such as a history of cholelithiasis or alcohol abuse. Fourteen cases of pancreatitis were reported in the comparator-treated.[Ref]

Immunologic

Pooled analysis of drug-treated patients has found that almost 70% were antibody positive at 24 weeks. Of the antibody positive patients, those with the highest antibody concentrations (greater than 100 nmol/L) had attenuated glycemic responses. Additionally, a higher incidence of allergic reactions and injection site reactions occurred in antibody positive patients.[Ref]

Metabolic

Nervous system

Cardiovascular

Genitourinary

Local

Musculoskeletal

Other

Respiratory

Dermatologic

Hypersensitivity

References

1. Cerner Multum, Inc. "Australian Product Information."

2. (2016) "Product Information. Adlyxin (lixisenatide)." sanofi-aventis

Frequently asked questions

Further information

Adlyxin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.