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Acrivastine / pseudoephedrine Side Effects

Medically reviewed by Last updated on Apr 29, 2023.

Applies to acrivastine / pseudoephedrine: oral capsule.


You should not use this medicine if you have severe or uncontrolled high blood pressure or coronary artery disease.

Do not use acrivastine and pseudoephedrine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Side effects such as dizziness, drowsiness, and urination problems may be more likely in older adults.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to acrivastine / pseudoephedrine: oral capsule.

Nervous system

Very common (10% or more): Headache (19%), somnolence (12%)

Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Dry mouth, nausea, dyspepsia[Ref]


Postmarketing reports: Serious hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, erythema multiforme)[Ref]


Common (1% to 10%): Insomnia, nervousness


Common (1% to 10%): Dysmenorrhea


Common (1% to 10%): Pharyngitis, cough increase


Common (1% to 10%): Asthenia


1. Product Information. Semprex-D (acrivastine-pseudoephedrine). Endo Laboratories LLC. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.