Skip to main content

Acetaminophen / Pheniramine / Phenylephrine Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 13, 2023.

Applies to acetaminophen / pheniramine / phenylephrine: oral powder for reconstitution.

Important warnings This medicine can cause some serious health issues

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

Do not use cold or allergy medicine if you have taken an MAO inhibitor in the past 14 days.

A dangerous drug interaction could occur.

MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Get emergency medical help if you have any of these signs of an allergic reaction while taking acetaminophen/pheniramine/phenylephrine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using the medicine and call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to acetaminophen/pheniramine/phenylephrine: oral powder for reconstitution.

Hepatic

Cardiovascular

Nervous system

Hematologic

Hypersensitivity

Gastrointestinal

Genitourinary

Ocular

References

1. "Product Information. Theraflu Cold and Sore Throat (acetaminophen / pheniramine / phenylephrine)." Novartis Consumer Health

Further information

Acetaminophen/pheniramine/phenylephrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.