Skip to Content


Medically reviewed by Last updated on Aug 10, 2019.


(GLIS er in)

Index Terms

  • Glycerol

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Enema, Rectal:

Fleet Liquid Glycerin Supp: 5.4 g/dose (7.5 mL)

Suppository, Rectal:

Pedia-Lax: 1 g (12 ea); 2.8 g (4 mL) [contains edetate disodium]

Sani-Supp Adult: 2 g (10 ea [DSC], 25 ea [DSC])

Sani-Supp Pediatric: 1.2 g (10 ea [DSC], 25 ea [DSC])

Generic: 1 g (12 ea, 25 ea); 2 g (12 ea, 24 ea, 25 ea, 50 ea)

Brand Names: U.S.

  • Fleet Liquid Glycerin Supp [OTC]
  • Pedia-Lax [OTC]
  • Sani-Supp Adult [OTC] [DSC]
  • Sani-Supp Pediatric [OTC] [DSC]

Pharmacologic Category

  • Laxative, Osmotic


Osmotic dehydrating agent which increases osmotic pressure; draws fluid into colon and thus stimulates evacuation


Rectal: Poorly absorbed

Onset of Action

Constipation: Suppository: 15 to 30 minutes

Use: Labeled Indications

Constipation: Relief of occasional constipation.

Mouth/throat irritation: Temporary relief of minor discomfort and protection of irritated areas in sore mouth and sore throat.

Dosing: Adult

Constipation: Rectal: One adult suppository once daily as needed or as directed

Mouth/throat irritation: Oral: Apply a one-inch strip directly to tongue and oral cavity as needed

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Fecal impaction, rapid disempaction: Limited data available: Rectal: Infants and Children <2 years: Suppository: 1 pediatric suppository once (Wyllie 2011)

Constipation: Rectal: Suppository:

Children 2 to 5 years: 1 pediatric suppository once daily as needed or as directed

Children ≥6 years and Adolescents: 1 adult suppository once daily as needed or as directed

Mouth/throat irritation: Oral: Oral gel: Children ≥2 years and Adolescents: Apply a 1-inch strip directly to tongue and oral cavity as needed


Oral: Apply gel to tongue and around inside and outside of tooth and gum surfaces; do not rinse out.

Rectal: Insert suppository high in the rectum and retain ~15 minutes; suppository does not need to melt to produce response


Store at room temperature; protect rectal products from heat.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

Frequency not defined.

Gastrointestinal: Abdominal cramps, rectal irritation, tenesmus


Dosage forms specific issues:

• Oral products: For use as an oral demulcent; do not swallow excessive amounts.

• Rectal products: May cause rectal discomfort or a burning sensation.

Pregnancy Considerations

Glycerin suppositories are generally considered safe to use during pregnancy (Cullen, 2007; Wald, 2003).

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience nausea, abdominal cramps, flatulence, diarrhea, burning, or rectal irritation. Have patient report immediately to prescriber severe abdominal pain, rectal pain, or rectal bleeding (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.