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Alfentanil

Pronunciation

(al FEN ta nil)

Index Terms

  • Afentanil HCl
  • Alfentanil Hydrochloride
  • Alfentanyl

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Injectable, Injection [preservative free]:

Alfenta: 500 mcg/mL (2 mL, 5 mL)

Generic: 500 mcg/mL (2 mL, 5 mL)

Brand Names: U.S.

  • Alfenta

Pharmacologic Category

  • Analgesic, Opioid
  • Anilidopiperidine Opioid

Pharmacology

Binds with stereospecific receptors at many sites within the CNS, increases pain threshold, alters pain perception, inhibits ascending pain pathways; is an ultra short-acting opioid

Distribution

Vd:

Newborns (premature): 0.5 to 0.6 L/kg (Davis 1988; Marlow 1990)

Children: 0.163 to 0.4 L/kg (Davis 1989; Meistelman 1987)

Adults: 0.4 to 1 L/kg

Metabolism

Hepatic

Excretion

Only 1% of dose is excreted unchanged; urine (major route of elimination of metabolites)

Onset of Action

Rapid, within 5 minutes

Duration of Action

Dose dependent: 30 to 60 minutes

Half-Life Elimination

Newborns (premature): 5.33 to 9 hours (Davis 1988; Marlow 1990)

Children: 40 to 63 minutes (Davis 1988; Meistelman 1987; Roure 1987)

Adults: 90 to 111 minutes

Protein Binding

Neonates: 67%; Adults: 88% to 92%; bound to alpha1-acid glycoprotein

Special Populations: Hepatic Function Impairment

Reduced plasma clearance and extended terminal elimination may develop.

Special Populations: Elderly

Reduced plasma clearance and extended terminal elimination may develop.

Use: Labeled Indications

Analgesia: Analgesic adjunct for the maintenance of anesthesia with barbiturate/nitrous oxide/oxygen; analgesic with nitrous oxide/oxygen in the maintenance of general anesthesia; analgesic component for monitored anesthesia care

Anesthetic: Primary anesthetic for induction of anesthesia in general surgery when endotracheal intubation and mechanical ventilation are required

Contraindications

Hypersensitivity to alfentanil or any component of the formulation or known intolerance to other opioid agonists

Dosing: Adult

Doses should be titrated to appropriate effects; wide range of doses is dependent upon desired degree of analgesia/anesthesia

Anesthesia: Base dose on actual body weight unless >20% above ideal body weight, then base dose on lean body weight.

Alfentanil

Indication

Approx Duration of Anesthesia (min)

Induction Period (Initial Dose) (mcg/kg)

Maintenance Period (Increments/ Infusion)

Total Dose (mcg/kg)

Effects

Incremental injection

≤30

8-20

3-5 mcg/kg every 5-20 minutes or 0.5-1 mcg/kg/min

8-40

Spontaneously breathing or assisted ventilation when required.

30-60

20-50

5-15 mcg/kg every 5-20 minutes

Up to 75

Assisted or controlled ventilation required. Attenuation of response to laryngoscopy and intubation.

Continuous infusion

>45

50-75

0.5-3 mcg/kg/min; average infusion rate 1-1.5 mcg/kg/min

Dependent on duration of procedure

Assisted or controlled ventilation required. Some attenuation of response to intubation and incision, with intraoperative stability.

Anesthetic induction

>45

130-245

0.5-1.5 mcg/kg/min or general anesthetic

Dependent on duration of procedure

Assisted or controlled ventilation required. Administer induction dose slowly (over 3 minutes). Concentration of inhalation agents reduced by 30% to 50% for initial hour.

Monitored Anesthesia Care (MAC)

3-8

3-5 mcg/kg every 5-20 minutes or 0.25-1 mcg/kg/min

3-40

Sedation, responsiveness, spontaneously breathing

Table has been converted to the following text.

Adult Dosage Adjustments

Incremental injection in anesthesia ≤30 minutes:

• Initial dose (induction period): 8-20 mcg/kg

• Maintenance period (increments/infusion): 3-5 mcg/kg every 5-20 minutes or 0.5-1 mcg/kg/min

• Total dose: 8-40 mcg/kg

• Appropriate effects: Spontaneously breathing or assisted ventilation when required

Incremental injection in anesthesia of 30-60 minutes:

• Initial dose (induction period): 20-50 mcg/kg

• Maintenance period (increments/infusion): 5-15 mcg/kg every 5-20 minutes

• Total dose: Up to 75 mcg/kg

• Appropriate effects: Assisted or controlled ventilation required. Attenuation of response to laryngoscopy and intubation.

Continuous infusion >45 minutes:

• Initial dose (induction period): 50-75 mcg/kg

• Maintenance period (increments/infusion): 0.5-3mcg/kg/min; average infusion rate: 1-1.5 mcg/kg/min

• Total dose: Dependent on duration of procedure

• Appropriate effects: Assisted or controlled ventilation required. Some attenuation of response to intubation and incision, with intraoperative stability.

Anesthetic induction >45 minutes:

• Initial dose (induction period): 130-245 mcg/kg

• Maintenance period (increments/infusion): 0.5-1.5 mcg/kg/minute or general anesthetic

• Total dose: Dependent on duration of procedure

• Appropriate effects: Assisted or controlled ventilation required. Administer induction dose slowly (over 3 minutes). Concentration of inhalation agents reduced by 30% to 50% for initial hour.

Monitored Anesthesia Care (MAC):

• Initial dose (induction period): 3-8 mcg/kg

• Maintenance period (increments/infusion): 3-5 mcg/kg every 5-20 minutes or 0.25-1 mcg/kg/min

• Total dose: 3-40 mcg/kg

• Appropriate effects: Sedation, responsiveness, spontaneously breathing

Dosing: Geriatric

Refer to adult dosing. Appropriately reduce the initial dose in elderly patients; consider the effect of the initial dose in determining supplemental doses.

Dosing: Pediatric

Children ≥12 years: Refer to adult dosing.

Dosing: Renal Impairment

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. The pharmacokinetics of alfentanil were evaluated in adult patients with chronic renal failure and compared to patients with normal renal function. Although Vdss was increased in patients with renal failure, elimination half-life was similar between the 2 groups (Chauvin, 1987). Therefore, prolongation of alfentanil duration of action is not expected and dosage adjustment is not necessary.

Dosing: Hepatic Impairment

There are no dosage adjustments provided in the manufacturer's labeling; use with caution.

Dosing: Obesity

In patients weighing >20% above ideal body weight, determine dose based on lean body weight.

Administration

Administer IV slowly over 3 minutes or by IV continuous infusion.

Compatibility

Stable in D5W, NS, LR, D5NS.

Y-site administration:

Compatible: Bivalirudin, cisatracurium, dexmedetomidine, etomidate, fenoldopam, hetastarch in lactate electrolyte injection (Hextend), linezolid, propofol, remifentanil.

Incompatible: Amphotericin B cholesteryl sulfate complex, thiopental.

Compatibility in syringe: Compatible: Atracurium, midazolam, morphine, ondansetron

Storage

Undiluted injectable: Store at 20°C to 25°C (68°F to 77°F). Protect from light.

Drug Interactions

Alvimopan: Analgesics (Opioid) may enhance the adverse/toxic effect of Alvimopan. This is most notable for patients receiving long-term (i.e., more than 7 days) opiates prior to alvimopan initiation. Management: Alvimopan is contraindicated in patients receiving therapeutic doses of opioids for more than 7 consecutive days immediately prior to alvimopan initiation. Consider therapy modification

Amphetamines: May enhance the analgesic effect of Analgesics (Opioid). Monitor therapy

Analgesics (Opioid): CNS Depressants may enhance the CNS depressant effect of Analgesics (Opioid). Management: Avoid concomitant use of opioid analgesics and benzodiazepines or other CNS depressants when possible. These agents should only be combined if alternative treatment options are inadequate. If combined, limit the dosages and duration of each drug. Consider therapy modification

Anticholinergic Agents: May enhance the adverse/toxic effect of Analgesics (Opioid). Specifically, the risk for constipation and urinary retention may be increased with this combination. Monitor therapy

Aprepitant: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Azelastine (Nasal): CNS Depressants may enhance the CNS depressant effect of Azelastine (Nasal). Avoid combination

Beta-Blockers: Anilidopiperidine Opioids may enhance the bradycardic effect of Beta-Blockers. Anilidopiperidine Opioids may enhance the hypotensive effect of Beta-Blockers. Monitor therapy

Blonanserin: CNS Depressants may enhance the CNS depressant effect of Blonanserin. Consider therapy modification

Brimonidine (Topical): May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Calcium Channel Blockers (Nondihydropyridine): Anilidopiperidine Opioids may enhance the bradycardic effect of Calcium Channel Blockers (Nondihydropyridine). Anilidopiperidine Opioids may enhance the hypotensive effect of Calcium Channel Blockers (Nondihydropyridine). Monitor therapy

Cannabis: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Chlorphenesin Carbamate: May enhance the adverse/toxic effect of CNS Depressants. Monitor therapy

Cimetidine: May increase the serum concentration of Alfentanil. Monitor therapy

CNS Depressants: May enhance the CNS depressant effect of Analgesics (Opioid). Management: Avoid concomitant use of opioid analgesics and benzodiazepines or other CNS depressants when possible. These agents should only be combined if alternative treatment options are inadequate. If combined, limit the dosages and duration of each drug. Consider therapy modification

Conivaptan: May increase the serum concentration of CYP3A4 Substrates. Avoid combination

Crizotinib: May increase the serum concentration of Alfentanil. Avoid combination

CYP3A4 Inhibitors (Moderate): May decrease the metabolism of CYP3A4 Substrates. Monitor therapy

CYP3A4 Inhibitors (Strong): May decrease the metabolism of CYP3A4 Substrates. Consider therapy modification

Dasatinib: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Desmopressin: Analgesics (Opioid) may enhance the adverse/toxic effect of Desmopressin. Monitor therapy

DiazePAM: May enhance the CNS depressant effect of Alfentanil. Hypotension may also occur. Monitor therapy

DilTIAZem: May increase the serum concentration of Alfentanil. Monitor therapy

Dimethindene (Systemic): May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Diuretics: Analgesics (Opioid) may enhance the adverse/toxic effect of Diuretics. Analgesics (Opioid) may diminish the therapeutic effect of Diuretics. Monitor therapy

Dronabinol: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Droperidol: May enhance the CNS depressant effect of CNS Depressants. Management: Consider dose reductions of droperidol or of other CNS agents (e.g., opioids, barbiturates) with concomitant use. Consider therapy modification

Eluxadoline: Analgesics (Opioid) may enhance the constipating effect of Eluxadoline. Avoid combination

Enzalutamide: May decrease the serum concentration of Alfentanil. Avoid combination

Fluconazole: May increase the serum concentration of Alfentanil. Management: Monitor for increased anesthetic and respiratory depressant effects if alfentanil is combined with fluconazole. Consider using lower initial doses of alfentanil or an alternative anesthetic. Consider therapy modification

Flunitrazepam: CNS Depressants may enhance the CNS depressant effect of Flunitrazepam. Consider therapy modification

Fosaprepitant: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Fusidic Acid (Systemic): May increase the serum concentration of CYP3A4 Substrates. Avoid combination

Gastrointestinal Agents (Prokinetic): Analgesics (Opioid) may diminish the therapeutic effect of Gastrointestinal Agents (Prokinetic). Monitor therapy

HYDROcodone: CNS Depressants may enhance the CNS depressant effect of HYDROcodone. Management: Avoid concomitant use of hydrocodone and benzodiazepines or other CNS depressants when possible. These agents should only be combined if alternative treatment options are inadequate. If combined, limit the dosages and duration of each drug. Consider therapy modification

Idelalisib: May increase the serum concentration of CYP3A4 Substrates. Avoid combination

Ivacaftor: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Kava Kava: May enhance the adverse/toxic effect of CNS Depressants. Monitor therapy

Lofexidine: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Luliconazole: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Macrolide Antibiotics: May increase the serum concentration of Alfentanil. Management: For patients receiving an interacting macrolide antibiotic, caution should be used in administering alfentanil; monitor for increased anesthetic and respiratory depressant effects. Consider using lower doses of alfentanil or an alternative anesthetic. Exceptions: Azithromycin (Systemic); Fidaxomicin; Roxithromycin; Spiramycin. Consider therapy modification

Magnesium Sulfate: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Methotrimeprazine: May enhance the CNS depressant effect of CNS Depressants. CNS Depressants may enhance the CNS depressant effect of Methotrimeprazine. Management: Reduce adult dose of CNS depressant agents by 50% with initiation of concomitant methotrimeprazine therapy. Further CNS depressant dosage adjustments should be initiated only after clinically effective methotrimeprazine dose is established. Consider therapy modification

MetyroSINE: CNS Depressants may enhance the sedative effect of MetyroSINE. Monitor therapy

MiFEPRIStone: May increase the serum concentration of CYP3A4 Substrates. Management: Minimize doses of CYP3A4 substrates, and monitor for increased concentrations/toxicity, during and 2 weeks following treatment with mifepristone. Avoid cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus. Consider therapy modification

Minocycline: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Mixed Agonist / Antagonist Opioids: May diminish the analgesic effect of Analgesics (Opioid). Management: Seek alternatives to mixed agonist/antagonist opioids in patients receiving pure opioid agonists, and monitor for symptoms of therapeutic failure/high dose requirements (or withdrawal in opioid-dependent patients) if patients receive these combinations. Avoid combination

Nabilone: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Nalmefene: May diminish the therapeutic effect of Analgesics (Opioid). Management: Avoid the concomitant use of nalmefene and opioid analgesics. Discontinue nalmefene 1 week prior to any anticipated use of opioid analgesics. If combined, larger doses of opioid analgesics will likely be required. Consider therapy modification

Naltrexone: May diminish the therapeutic effect of Analgesics (Opioid). Management: Seek therapeutic alternatives to opioids. See full drug interaction monograph for detailed recommendations. Consider therapy modification

Netupitant: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir: May increase the serum concentration of Alfentanil. Management: Monitor for increased anesthetic and respiratory depressant effects of alfentanil if these agents are combined. Consider using lower initial doses of alfentanil or an alternative anesthetic. Canadian labeling recommends avoidance of this combination. Consider therapy modification

Orphenadrine: CNS Depressants may enhance the CNS depressant effect of Orphenadrine. Avoid combination

OxyCODONE: CNS Depressants may enhance the CNS depressant effect of OxyCODONE. Management: Avoid concomitant use of oxycodone and benzodiazepines or other CNS depressants when possible. These agents should only be combined if alternative treatment options are inadequate. If combined, limit the dosages and duration of each drug. Consider therapy modification

Palbociclib: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Paraldehyde: CNS Depressants may enhance the CNS depressant effect of Paraldehyde. Avoid combination

Pegvisomant: Analgesics (Opioid) may diminish the therapeutic effect of Pegvisomant. Monitor therapy

Perampanel: May enhance the CNS depressant effect of CNS Depressants. Management: Patients taking perampanel with any other drug that has CNS depressant activities should avoid complex and high-risk activities, particularly those such as driving that require alertness and coordination, until they have experience using the combination. Consider therapy modification

Piribedil [INT]: CNS Depressants may enhance the CNS depressant effect of Piribedil [INT]. Monitor therapy

Pramipexole: CNS Depressants may enhance the sedative effect of Pramipexole. Monitor therapy

Propofol: Alfentanil may enhance the adverse/toxic effect of Propofol. Specifically the development of opisthotonus (severe hyperextension and spasticity resulting in arching or bridging position) and/or grand mal seizures. Monitor therapy

Ramosetron: Analgesics (Opioid) may enhance the constipating effect of Ramosetron. Monitor therapy

Rifamycin Derivatives: May decrease the serum concentration of Alfentanil. Management: Monitor closely for decreased alfentanil effectiveness. Increased alfentanil doses will likely be needed. Alternatively, changing from alfentanil to a different opioid anesthetic (e.g., sufentanil) may also be considered. Consider therapy modification

ROPINIRole: CNS Depressants may enhance the sedative effect of ROPINIRole. Monitor therapy

Rotigotine: CNS Depressants may enhance the sedative effect of Rotigotine. Monitor therapy

Rufinamide: May enhance the adverse/toxic effect of CNS Depressants. Specifically, sleepiness and dizziness may be enhanced. Monitor therapy

Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake Inhibitors. Specifically, the risk of psychomotor impairment may be enhanced. Monitor therapy

Serotonin Modulators: Analgesics (Opioid) may enhance the serotonergic effect of Serotonin Modulators. This could result in serotonin syndrome. Exceptions: Nicergoline. Monitor therapy

Simeprevir: May increase the serum concentration of CYP3A4 Substrates. Monitor therapy

Sodium Oxybate: May enhance the CNS depressant effect of CNS Depressants. Management: Consider alternatives to combined use. When combined use is needed, consider minimizing doses of one or more drugs. Use of sodium oxybate with alcohol or sedative hypnotics is contraindicated. Consider therapy modification

Stiripentol: May increase the serum concentration of CYP3A4 Substrates. Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity. Any CYP3A4 substrate used with stiripentol requires closer monitoring. Consider therapy modification

Succinylcholine: May enhance the bradycardic effect of Analgesics (Opioid). Monitor therapy

Suvorexant: CNS Depressants may enhance the CNS depressant effect of Suvorexant. Management: Dose reduction of suvorexant and/or any other CNS depressant may be necessary. Use of suvorexant with alcohol is not recommended, and the use of suvorexant with any other drug to treat insomnia is not recommended. Consider therapy modification

Tapentadol: May enhance the CNS depressant effect of CNS Depressants. Management: Avoid concomitant use of tapentadol and benzodiazepines or other CNS depressants when possible. These agents should only be combined if alternative treatment options are inadequate. If combined, limit the dosages and duration of each drug. Consider therapy modification

Tetrahydrocannabinol: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy

Thalidomide: CNS Depressants may enhance the CNS depressant effect of Thalidomide. Avoid combination

Zolpidem: CNS Depressants may enhance the CNS depressant effect of Zolpidem. Management: Reduce the Intermezzo brand sublingual zolpidem adult dose to 1.75 mg for men who are also receiving other CNS depressants. No such dose change is recommended for women. Avoid use with other CNS depressants at bedtime; avoid use with alcohol. Consider therapy modification

Adverse Reactions

>10%:

Cardiovascular: Bradycardia, peripheral vasodilation

Central nervous system: Drowsiness, increased intracranial pressure, sedation

Endocrine & metabolic: Increased release of antidiuretic hormone

Gastrointestinal: Constipation, nausea, vomiting

Ophthalmic: Miosis

1% to 10%:

Cardiovascular: Cardiac arrhythmia, orthostatic hypotension

Central nervous system: Central nervous system depression, confusion

Ophthalmic: Blurred vision

<1% (Limited to important or life-threatening): Biliary tract spasm, bronchospasm, cold and clammy skin, convulsions, delirium, depression, dizziness, drug dependence, dysesthesia, genitourinary tract spasm, laryngospasm, paradoxical central nervous system stimulation, pruritus, respiratory depression, skin rash, urticaria

Warnings/Precautions

Concerns related to adverse effects:

• Hypotension: May cause hypotension; use with caution in patients with hypovolemia, cardiovascular disease (including acute MI), or drugs which may exaggerate hypotensive effects (including phenothiazines or general anesthetics).

• Opioid agonist toxicities: Shares the toxic potentials of opioid agonists, and precautions of opioid agonist therapy should be observed.

Disease-related concerns:

• Bradyarrhythmias: Bradycardia has been observed in patients receiving alfentanil; use with caution when administering to patients with bradyarrhythmias. Degree of bradycardia may be more pronounced when administered with non-vagolytic skeletal muscle relaxants (eg, vecuronium, cisatracurium) or when anticholinergic agents (eg, atropine) are not used.

• Drug abuse: Use with caution in patients with a history of drug abuse or acute alcoholism; potential for drug dependency exists. Tolerance, psychological and physical dependence may occur with prolonged use.

• Head trauma: Use with extreme caution in patients with head injury, intracranial lesions, or elevated intracranial pressure; exaggerated elevation of ICP may occur.

• Hepatic impairment: Use with caution in patients with hepatic impairment; duration of action may be prolonged.

• Obesity: Use with caution in patients who are morbidly obese. Use lean body weight for dosing in patients >20% over ideal body weight.

• Renal impairment: Use with caution in patients with renal impairment.

• Respiratory disease: Use with caution in patients with preexisting respiratory compromise (hypoxia and/or hypercapnia), COPD or other obstructive pulmonary disease, and kyphoscoliosis or other skeletal disorder which may alter respiratory function.

• Skeletal muscle rigidity: Skeletal muscle rigidity is related to the dose and rate of administration. Inject slowly over 3 minutes; rapid IV infusion may result in skeletal muscle and chest wall rigidity, impaired ventilation, or respiratory distress/arrest. Initial doses up to 20 mcg/kg may cause skeletal muscle rigidity. Doses >130 mcg/kg will consistently cause muscle rigidity with an immediate onset. Consider the concomitant use of a nondepolarizing skeletal muscle relaxant to decrease the incidence.

Concurrent drug therapy issues:

• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.

Special populations:

• Debilitated patients: Appropriately reduce the initial dose in debilitated patients; consider the effect of the initial dose in determining supplemental doses.

• Elderly: Appropriately reduce the initial dose in elderly patients; consider the effect of the initial dose in determining supplemental doses. Plasma clearance of alfentanil may be reduced and postoperative recovery may be prolonged.

Other warnings/precautions:

• Trained individuals: Due to the high incidence of apnea, hypotension, tachycardia, and muscle rigidity, alfentanil should be administered by individuals specifically trained in the use of anesthetic agents and should not be used in diagnostic or therapeutic procedures outside the monitored anesthesia setting; opioid antagonist, resuscitative and intubation equipment should be readily available.

Monitoring Parameters

Continuously monitor respiratory rate, oxygen saturation, blood pressure, heart rate; monitor the patient well after surgery because of the risk for delayed effects

Pregnancy Risk Factor

C

Pregnancy Considerations

Adverse events were observed in some animal reproduction studies. Alfentanil is known to cross the placenta, which may result in severe respiratory depression in the newborn (Mattingly, 2003). When used for pain relief during labor, opioids may temporarily affect the heart rate of the fetus (ACOG, 2002). Use during labor and delivery is not recommended by the manufacturer.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience fatigue, vomiting, or nausea. Have patient report immediately to prescriber severe dizziness, passing out, bradycardia, tachycardia, arrhythmia, difficult breathing, slow breathing, shallow breathing, confusion, confusion, sexual dysfunction (males), amenorrhea, decreased libido, infertility, signs of adrenal gland problems (severe nausea, vomiting, severe dizziness, passing out, muscle weakness, severe fatigue, mood changes, lack of appetite, or weight loss), or signs of serotonin syndrome (dizziness, severe headache, agitation, hallucinations, tachycardia, abnormal heartbeat, flushing, tremors, sweating a lot, change in balance, severe nausea, or severe diarrhea) (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

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