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Alfentanil Dosage

Applies to the following strengths: 0.5 mg/mL

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anesthesia

Doses should be individualized and titrated to the desired effect according to body weight, physical status, underlying pathological condition, use of other drugs, and type and duration of surgical procedure, and anesthesia:

Induction of Analgesia: 8 to 20 mcg/kg IV
Maintenance of Analgesia: 3 to 5 mcg/kg IV every 5 to 20 minutes or 0.5 to 1 mcg/kg/min IV
Total dose: 8 to 40 mcg/kg

Induction of analgesia: 20 to 50 mcg/kg IV
Maintenance of analgesia: 5 to 15 mcg/kg IV every 5 to 20 minutes
Total dose: Up to 75 mcg/kg
Induction of analgesia: 50 to 75 mcg/kg IV
Maintenance of analgesia: 0.5 to 3 mcg/kg/min IV (average rate 1 to 1.5 mcg/kg/min); infusion rates are variable and should be titrated to the desired clinical effect
Total dose: Dependent on duration of procedure

Induction of analgesia: 130 to 245 mcg/kg IV slowly over 3 minutes
Maintenance of analgesia: 0.5 to 1.5 mcg/kg/min or general anesthetic
Total dose: Dependent on duration of procedure

Induction of MAC: 3 to 8 mcg/kg
Maintenance of MAC 3 to 5 mcg/kg every OR 0.25 to 1 mcg/kg/min
Total dose: 3 to 40 mcg/kg

CONTINUOUS INFUSIONS:
Infusion Rate: 0.5 to 3 mcg/min

Comments:

Uses:

Usual Adult Dose for Pain

Doses should be individualized and titrated to the desired effect according to body weight, physical status, underlying pathological condition, use of other drugs, and type and duration of surgical procedure, and anesthesia:

Induction of Analgesia: 8 to 20 mcg/kg IV
Maintenance of Analgesia: 3 to 5 mcg/kg IV every 5 to 20 minutes or 0.5 to 1 mcg/kg/min IV
Total dose: 8 to 40 mcg/kg

Induction of analgesia: 20 to 50 mcg/kg IV
Maintenance of analgesia: 5 to 15 mcg/kg IV every 5 to 20 minutes
Total dose: Up to 75 mcg/kg
Induction of analgesia: 50 to 75 mcg/kg IV
Maintenance of analgesia: 0.5 to 3 mcg/kg/min IV (average rate 1 to 1.5 mcg/kg/min); infusion rates are variable and should be titrated to the desired clinical effect
Total dose: Dependent on duration of procedure

Induction of analgesia: 130 to 245 mcg/kg IV slowly over 3 minutes
Maintenance of analgesia: 0.5 to 1.5 mcg/kg/min or general anesthetic
Total dose: Dependent on duration of procedure

Induction of MAC: 3 to 8 mcg/kg
Maintenance of MAC 3 to 5 mcg/kg every OR 0.25 to 1 mcg/kg/min
Total dose: 3 to 40 mcg/kg

CONTINUOUS INFUSIONS:
Infusion Rate: 0.5 to 3 mcg/min

Comments:

Uses:

Usual Geriatric Dose for Anesthesia

Initial dose: Reduce usual adult dose by up to 40% to account for reduced clearance and increased sensitivity

Usual Geriatric Dose for Pain

Initial dose: Reduce usual adult dose by up to 40% to account for reduced clearance and increased sensitivity

Usual Pediatric Dose for Anesthesia

Doses should be individualized and titrated to the desired effect according to body weight, physical status, underlying pathological condition, use of other drugs, and type and duration of surgical procedure, and anesthesia:

12 years or older:

Induction of Analgesia: 8 to 20 mcg/kg IV
Maintenance of Analgesia: 3 to 5 mcg/kg IV every 5 to 20 minutes or 0.5 to 1 mcg/kg/min IV
Total dose: 8 to 40 mcg/kg

Induction of analgesia: 20 to 50 mcg/kg IV
Maintenance of analgesia: 5 to 15 mcg/kg IV every 5 to 20 minutes
Total dose: Up to 75 mcg/kg
Induction of analgesia: 50 to 75 mcg/kg IV
Maintenance of analgesia: 0.5 to 3 mcg/kg/min IV (average rate 1 to 1.5 mcg/kg/min); infusion rates are variable and should be titrated to the desired clinical effect
Total dose: Dependent on duration of procedure

Induction of analgesia: 130 to 245 mcg/kg IV slowly over 3 minutes
Maintenance of analgesia: 0.5 to 1.5 mcg/kg/min or general anesthetic
Total dose: Dependent on duration of procedure

Induction of MAC: 3 to 8 mcg/kg
Maintenance of MAC 3 to 5 mcg/kg every OR 0.25 to 1 mcg/kg/min
Total dose: 3 to 40 mcg/kg

CONTINUOUS INFUSIONS:
Infusion Rate: 0.5 to 3 mcg/min

Comments:

Uses:

Usual Pediatric Dose for Pain

Doses should be individualized and titrated to the desired effect according to body weight, physical status, underlying pathological condition, use of other drugs, and type and duration of surgical procedure, and anesthesia:

12 years or older:

Induction of Analgesia: 8 to 20 mcg/kg IV
Maintenance of Analgesia: 3 to 5 mcg/kg IV every 5 to 20 minutes or 0.5 to 1 mcg/kg/min IV
Total dose: 8 to 40 mcg/kg

Induction of analgesia: 20 to 50 mcg/kg IV
Maintenance of analgesia: 5 to 15 mcg/kg IV every 5 to 20 minutes
Total dose: Up to 75 mcg/kg
Induction of analgesia: 50 to 75 mcg/kg IV
Maintenance of analgesia: 0.5 to 3 mcg/kg/min IV (average rate 1 to 1.5 mcg/kg/min); infusion rates are variable and should be titrated to the desired clinical effect
Total dose: Dependent on duration of procedure

Induction of analgesia: 130 to 245 mcg/kg IV slowly over 3 minutes
Maintenance of analgesia: 0.5 to 1.5 mcg/kg/min or general anesthetic
Total dose: Dependent on duration of procedure

Induction of MAC: 3 to 8 mcg/kg
Maintenance of MAC 3 to 5 mcg/kg every OR 0.25 to 1 mcg/kg/min
Total dose: 3 to 40 mcg/kg

CONTINUOUS INFUSIONS:
Infusion Rate: 0.5 to 3 mcg/min

Comments:

Uses:

Renal Dose Adjustments

Use with caution, dosage adjustments may be required; however, no specific guidelines have been suggested.

Liver Dose Adjustments

Use with caution, dosage adjustments may be required; however, no specific guidelines have been suggested.

Dose Adjustments

Obese Patients (more than 20% above ideal body weight): Dose on ideal body weight

Concomitant Use of Other CNS Depressants:


To Reduce Incidence of Skeletal Muscle Rigidity:

Continuous Infusion Dose Adjustments:

Discontinuation:

Precautions

US BOXED WARNING: ADDICTION, ABUSE, AND MISUSE:


Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient Advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.