Generic Name: protriptyline (proe TRIP ti leen)
Brand Name: Vivactil
What is Vivactil (protriptyline)?
Protriptyline is a tricyclic antidepressant. Protriptyline affects chemicals in the brain that may be unbalanced in people with depression.
Protriptyline is used to treat symptoms of depression.
Protriptyline may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Vivactil (protriptyline)?
You should not use protriptyline if you have recently had a heart attack, or if you are allergic to certain medicines.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
What should I discuss with my healthcare provider before taking Vivactil (protriptyline)?
You should not use protriptyline if you are allergic to it, or if:
you have recently had a heart attack; or
you are allergic to similar antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, trimipramine).
Do not use protriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
To make sure protriptyline is safe for you, tell your doctor if you have:
heart disease, or a history of heart attack, stroke, or seizures;
bipolar disorder (manic-depression);
schizophrenia or other mental illness;
a thyroid disorder;
diabetes (protriptyline may raise or lower blood sugar);
narrow-angle glaucoma; or
problems with urination.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using protriptyline. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether protriptyline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether protriptyline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not give this medicine to a child without medical advice. Protriptyline is not approved for use in children.
How should I take Vivactil (protriptyline)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
If you need surgery, tell the surgeon ahead of time that you are using protriptyline. You may need to stop using the medicine for a short time.
Do not stop using protriptyline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using protriptyline.
It may take a few weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of protriptyline can be fatal.
What should I avoid while taking Vivactil (protriptyline)?
Do not drink alcohol. Protriptyline can increase the effects of alcohol, which could be dangerous.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid exposure to sunlight or tanning beds. Protriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Vivactil (protriptyline) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
restless muscle movements in your eyes, tongue, jaw, or neck;
a light-headed feeling, like you might pass out;
new or worsening chest pain, pounding heartbeats or fluttering in your chest;
sudden numbness or weakness, problems with vision, speech, or balance;
fever, sore throat, easy bruising, unusual bleeding;
painful or difficult urination; or
jaundice (yellowing of the skin or eyes).
Older adults may be more likely to have side effects from this medication.
Common side effects may include:
nausea, vomiting, loss of appetite;
anxiety, sleep problems (insomnia);
dry mouth, unusual taste;
little or no urinating;
breast swelling (in men or women); or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Vivactil (protriptyline)?
Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking protriptyline with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Before taking protriptyline, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline. You must wait at least 5 weeks after stopping fluoxetine (Prozac) before you can take protriptyline.
Many drugs can interact with protriptyline. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with protriptyline. Give a list of all your medicines to any healthcare provider who treats you.
More about Vivactil (protriptyline)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Español
- 1 Review – Add your own review/rating
- Drug class: tricyclic antidepressants
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about protriptyline.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 8.04.
Date modified: July 24, 2017
Last reviewed: July 20, 2016