What is Retavase?
Retavase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
Retavase may also be used for purposes not listed in this medication guide.
If possible before you receive Retavase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure, hemophilia or other bleeding disorder, a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord.
Before taking this medicine
You should not be treated with Retavase if you are allergic to it, or if you have:
active bleeding inside your body;
a bleeding or blood clotting disorder such as hemophilia;
a brain tumor or blood vessel disorder;
a brain aneurysm (dilated blood vessel);
severe uncontrolled high blood pressure;
a history of stroke; or
a recent history of head injury, or surgery on your brain or spinal cord.
If possible before you receive Retavase, tell your doctor if you have ever had:
a major surgery, medical trauma, or injury;
bleeding in your brain, stomach, intestines, or urinary tract;
a stroke; or
high blood pressure.
In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received Retavase.
If possible before you receive Retavase, tell your caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.
How is Retavase given?
Retavase is given as an infusion into a vein. A healthcare provider will give you this injection.
Retavase is usually given in two injections 30 minutes apart.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Retavase.
What happens if I miss a dose?
Because you will receive Retavase in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid after receiving Retavase?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Retavase side effects
Get emergency medical help if you have signs of an allergic reaction: hives, rash, itching, skin redness; difficult breathing; swelling of your face, lips, tongue, or throat.
Retavase increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.
Call your doctor at once if you have signs of bleeding inside your body, such as:
easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection);
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
red or pink urine; or
Also call your doctor at once if you have:
chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
severe headache, blurred vision, pounding in your neck or ears;
swelling, rapid weight gain, little or no urinating;
severe pain in your upper stomach spreading to your back, nausea and vomiting;
darkening or purple discoloration of your fingers or toes;
very slow heartbeats, shortness of breath, feeling light-headed; or
sudden severe back pain, muscle weakness, numbness or loss of feeling in your arms or legs.
Common side effects may include nausea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Retavase?
Tell your doctor about all your other medicines, especially:
Yes, Activase is the same as tPA but technically tPA is an abbreviation for tissue plasminogen activator which is the drug class that encompasses all tissue plasminogen activators, of which there are 3 that have been FDA approved in the United States, namely Activase (generic name alteplase), Retavase (generic name reteplase), TNKase (generic name Tenecteplase). Sometimes healthcare professionals use "tPA" to refer to Activase because it was the first tissue plasminogen activator that was approved. But errors may arise because staff get confused between the abbreviation TNK and tPA, which has resulted in TNKase being given to a stroke patient instead of the intended Activase (TNKase is not approved for stroke patients).
More about Retavase (reteplase)
- Side effects
- Drug interactions
- Dosage information
- During pregnancy
- Pricing & coupons
- En español
- Drug class: thrombolytics
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2022 Cerner Multum, Inc. Version: 3.02.