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Isopto Homatropine

Generic name: homatropine ophthalmichoe-ma-TROE-peen ]
Brand names: Homatropaire, Isopto Homatropine
Drug class: Mydriatics

Medically reviewed by on Aug 4, 2023. Written by Cerner Multum.

What is Isopto Homatropine?

Homatropine relaxes muscles in the iris (the colored part) of your eye. Relaxing these muscles helps to dilate or widen your pupil.

Isopto Homatropine (for the eyes) is used to treat an eye condition called uveitis. Isopto Homatropine is also used to dilate your pupil before an eye exam, or to lower pressure inside the eye after eye surgery.

Isopto Homatropine may also be used for purposes not listed in this medication guide.

Isopto Homatropine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when homatropine is used in the eyes, side effects can occur if the medicine is absorbed into your bloodstream.

Isopto Homatropine may cause serious side effects. Call your doctor at once if you have:

  • eye swelling or redness, crusting or drainage;

  • red or puffy eyelids;

  • confusion, agitation; or

  • unusual thoughts or behavior.

Common side effects of Isopto Homatropine may include:

  • stinging and burning after using the eye drops;

  • dry mouth, increased thirst; or

  • increased sensitivity of your eyes to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use Isopto Homatropine if you have glaucoma.

Before taking this medicine

You should not use this medicine if you are allergic to homatropine, or if you have:

  • glaucoma, or

  • if your eye doctor has found changes in your eyes that could be signs of glaucoma.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether homatropine ophthalmic passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Isopto Homatropine?

Follow all directions on your prescription label. Do not use Isopto Homatropine in larger or smaller amounts or for longer than recommended.

Do not use this medicine while wearing contact lenses. Isopto Homatropine may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

To treat uveitis, you may need to use Isopto Homatropine every 3 to 4 hours.

Wash your hands before using the eye drops.

To apply the eye drops:

  • Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.

  • Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.

  • Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops.

  • Wait at least 10 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Isopto Homatropine?

Isopto Homatropine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Isopto Homatropine can make your eyes more sensitive to light. Protect your eyes when you are outdoors in sunlight.

What other drugs will affect Isopto Homatropine?

It is not likely that other drugs you take orally or inject will have an effect on homatropine used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

More about Isopto Homatropine (homatropine ophthalmic)

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.