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Isopto Homatropine Side Effects

Generic Name: homatropine ophthalmic

Note: This page contains information about the side effects of homatropine ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Isopto Homatropine.

For the Consumer

Applies to homatropine ophthalmic: ophthalmic solution

Side effects include:

Elevated IOP, transient stinging, burning. With prolonged administration, local irritation (characterized by follicular conjunctivitis, vascular congestion, edema, exudate, and eczematoid dermatitis ), thirst, dry mouth, increased light sensitivity of eyes.

For Healthcare Professionals

Applies to homatropine ophthalmic: compounding powder, ophthalmic solution


Ocular side effects have included transient stinging and burning, eye irritation, and increased sensitivity to light. Prolonged use may produce local irritation characterized by follicular conjunctivitis, vascular congestion, edema, exudate and an eczematoid dermatitis.[Ref]


Gastrointestinal side effects have included thirst and dry mouth.[Ref]

Nervous system

Nervous system effects due to chronic use of the drug can lead to a confusional state characterized by delirium, agitation, and rarely coma. This state is associated with use in the pediatric and geriatric age groups.[Ref]

The specific antidote for this systemic anticholinergic syndrome is injectable physostigmine salicylate.[Ref]


1. "Product Information. Isopto Homatropine (homatropine ophthalmic)." Southwood Pharmaceuticals Inc, Irvine, CA.

Not all side effects for Isopto Homatropine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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