iron dextran
Generic Name: iron dextran (EYE urn DEX tran)
Brand Name: DexFerrum, Infed
What is iron dextran?
Iron dextran is a form of the mineral iron. Iron is important for many functions in the body, especially for the transport of oxygen in the blood.
Iron dextran is used to treat iron deficiencies and iron deficiency anemia (low red blood cells).
Iron dextran may also be used for purposes not listed in this medication guide.
What is the most important information I should know about iron dextran?
You should not receive iron dextran if you have a type of anemia that is not caused by iron deficiency.
Iron dextran can cause severe and sometimes fatal allergic reactions or severely low blood pressure. Tell your caregiver right away if you feel lightheaded (like you might pass out), or if you suddenly have trouble breathing.
What should I discuss with my healthcare provider before receiving iron dextran?
You should not receive iron dextran if you are allergic to it, or if you have a type of anemia that is not caused by iron deficiency.
To make sure iron dextran is safe for you, tell your doctor if you have:

heart disease;

liver disease;

kidney disease (or if you are on dialysis);

rheumatoid arthritis;

bleeding or blood clotting disorder such as hemophilia;

stomach bleeding;

asthma or allergies;

if you are allergic to any medication; or

if you use a betablocker medicine (atenolol, carvedilol, metoprolol, nebivolol, propranolol, sotalol, and others).
FDA pregnancy category C. It is not known whether iron dextran will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
Iron dextran can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.
How is iron dextran given?
Iron dextran is injected into a vein through an IV. You may be shown how to use an IV at home. Do not selfinject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Iron dextran must be given slowly. Injecting this medicine too quickly can cause serious side effects.
Your doctor may want to give your first dose of this medicine in a hospital to quickly treat any serious side effects that occur.
If you use this medicine at home, prepare your dose only when you are ready to give the injection. Do not mix iron dextran with other medicines or liquid (diluent) in the same syringe or IV container. Do not use iron dextran if it has changed colors or has particles in it. Call your pharmacist for new medicine.
Tell your doctor if you have any changes in height or weight. Iron dextran doses are based on these measures.
To be sure this medicine is helping your condition, you may need frequent blood tests. You may not notice any change in your symptoms, but your blood work will help your doctor determine how long to treat you with iron dextran.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using iron dextran.
Each singleuse vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of iron dextran.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 18002221222.
Overdose symptoms may include joint pain, chills, dizziness, fever, headache, muscle aches, nausea, and vomiting.
What should I avoid while using iron dextran?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Iron dextran side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Iron dextran can cause severe and sometimes fatal allergic reactions or severely low blood pressure. Tell your caregiver right away if you feel lightheaded or if you suddenly have trouble breathing.
Call your doctor at once if you have:

fast or slow heartbeats. chest pain, wheezing, trouble breathing;

a lightheaded feeling, like you might pass out;

flushing (warmth, redness, or tingly feeling);

bluecolored lips or fingernails;

red or pink urine;

weak or shallow breathing (breathing may stop);

seizure (convulsions);

swelling, warmth, redness, or itching where the medicine was injected; or

delayed effect (12 days after injection)fever, chills, dizziness, headache, general ill feeling, nausea and vomiting, joint or muscle pain, back pain.
Common side effects may include:

mild itching or rash;

body aches, numbness or tingly feeling;

nausea, vomiting, stomach pain, diarrhea;

mild dizziness or weakness, low fever; or

brown discoloration of your skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1800FDA1088.
See also: Side effects (in more detail)
Iron dextran dosing information
Usual Adult Dose for Iron Deficiency Anemia:
Administer doses of 2 mL or less, IV, once a day, until the calculated total amount required has been reached
Dose (mL) = 0.0442 (Desired hemoglobin  Observed hemoglobin) x lean body weight in kg + (0.26 x lean body weight)
Males: Lean Body Weight = 50 kg + 2.3 kg per inch in height over 60 inches
Females: Lean Body Weight = 45.5 kg + 2.3 kg per inch in height over 60 inches
OR
Weight in kg: mL drug if Hgb is: 3 g/dL; 4 g/dL; 5 g/dL; 6 g/dL; 7 g/dL; 8 g/dL; 9 g/dL; 10 g/dL
5 kg: 3 mL (3 g/dL); 3 mL (4 g/dL); 3 mL (5 g/dL); 3 mL (6 g/dL); 2 mL (7 g/dL); 2 mL (8 g/dL); 2 mL (9 g/dL); 2 mL (10 g/dL)
10 kg: 7 mL (3 g/dL); 6 mL (4 g/dL); 6 mL (5 g/dL); 5 mL (6 g/dL); 5 mL (7 g/dL); 4 mL (8 g/dL); 4 mL (9 g/dL); 3 mL (10 g/dL)
15 kg: 10 mL (3 g/dL); 9 mL (4 g/dL); 9 mL (5 g/dL); 8 mL (6 g/dL); 7 mL (7 g/dL); 7 mL (8 g/dL); 6 mL (9 g/dL); 5 mL (10 g/dL)
20 kg: 16 mL (3 g/dL); 15 mL (4 g/dL); 14 mL (5 g/dL); 13 mL (6 g/dL); 12 mL (7 g/dL); 11 mL (8 g/dL); 10 mL (9 g/dL); 9 mL (10 g/dL)
25 kg: 20 mL (3 g/dL); 18 mL (4 g/dL); 17 mL (5 g/dL); 16 mL (6 g/dL); 15 mL (7 g/dL); 14 mL (8 g/dL); 13 mL (9 g/dL); 12 mL (10 g/dL)
30 kg: 23 mL (3 g/dL); 22 mL (4 g/dL); 21 mL (5 g/dL); 19 mL (6 g/dL); 18 mL (7 g/dL); 17 mL (8 g/dL); 15 mL (9 g/dL); 14 mL (10 g/dL)
35 kg: 3 mL (3 g/dL); 27 mL (4 g/dL); 26 mL (5 g/dL); 24 mL (6 g/dL); 23 mL (7 g/dL); 20 mL (8 g/dL); 18 mL (9 g/dL); 17 mL (10 g/dL)
40 kg: 31 mL (3 g/dL); 29 mL (4 g/dL); 28 mL (5 g/dL); 26 mL (6 g/dL); 24 mL (7 g/dL); 22 mL (8 g/dL); 21 mL (9 g/dL); 19 mL (10 g/dL)
45 kg: 35 mL (3 g/dL); 35 mL (4 g/dL); 31 mL (5 g/dL); 29 mL (6 g/dL); 27 mL (7 g/dL); 25 mL (8 g/dL); 23 mL (9 g/dL); 21 mL (10 g/dL)
50 kg: 39 mL (3 g/dL); 37 mL (4 g/dL); 35 mL (5 g/dL); 32 mL (6 g/dL); 30 mL (7 g/dL); 28 mL (8 g/dL); 26 mL (9 g/dL); 24 mL (10 g/dL)
55 kg: 43 mL (3 g/dL); 41 mL (4 g/dL); 38 mL (5 g/dL); 36 mL (6 g/dL); 33 mL (7 g/dL); 31 mL (8 g/dL); 28 mL (9 g/dL); 26 mL (10 g/dL)
60 kg: 47 mL (3 g/dL); 44 mL (4 g/dL); 42 mL (5 g/dL); 39 mL (6 g/dL); 36 mL (7 g/dL); 34 mL (8 g/dL); 31 mL (9 g/dL); 28 mL (10 g/dL)
65 kg: 51 mL (3 g/dL); 48 mL (4 g/dL); 45 mL (5 g/dL); 42 mL (6 g/dL); 39 mL (7 g/dL); 36 mL (8 g/dL); 34 mL (9 g/dL); 31 mL (10 g/dL)
70 kg: 55 mL (3 g/dL); 52 mL (4 g/dL); 49 mL (5 g/dL); 45 mL (6 g/dL); 42 mL (7 g/dL); 39 mL (8 g/dL); 36 mL (9 g/dL); 33 mL (10 g/dL)
75 kg: 59 mL (3 g/dL); 55 mL (4 g/dL); 52 mL (5 g/dL); 49 mL (6 g/dL); 45 mL (7 g/dL); 42 mL (8 g/dL); 39 mL (9 g/dL); 35 mL (10 g/dL)
80 kg: 63 mL (3 g/dL); 59 mL (4 g/dL); 55 mL (5 g/dL); 52 mL (6 g/dL); 48 mL (7 g/dL); 45 mL (8 g/dL); 41 mL (9 g/dL); 38 mL (10 g/dL)
85 kg: 66 mL (3 g/dL); 63 mL (4 g/dL); 59 mL (5 g/dL); 55 mL (6 g/dL); 51 mL (7 g/dL); 48 mL (8 g/dL); 44 mL (9 g/dL); 40 mL (10 g/dL)
90 kg: 70 mL (3 g/dL); 66 mL (4 g/dL); 62 mL (5 g/dL); 58 mL (6 g/dL); 54 mL (7 g/dL); 50 mL (8 g/dL); 46 mL (9 g/dL); 42 mL (10 g/dL)
95 kg: 74 mL (3 g/dL); 70 mL (4 g/dL); 66 mL (5 g/dL); 62 mL (6 g/dL); 57 mL (7 g/dL); 53 mL (8 g/dL); 49 mL (9 g/dL); 45 mL (10 g/dL)
100 kg: 78 mL (3 g/dL); 74 mL (4 g/dL); 69 mL (5 g/dL); 65 mL (6 g/dL); 60 mL (7 g/dL); 56 mL (8 g/dL); 52 mL (9 g/dL); 47 mL (10 g/dL)
105 kg: 82 mL (3 g/dL); 77 mL (4 g/dL); 73 mL (5 g/dL); 68 mL (6 g/dL); 63 mL (7 g/dL); 59 mL (8 g/dL); 54 mL (9 g/dL); 10 mL (10 g/dL)
110 kg: 86 mL (3 g/dL); 81 mL (4 g/dL); 76 mL (5 g/dL); 71 mL (6 g/dL); 67 mL (7 g/dL); 62 mL (8 g/dL); 57 mL (9 g/dL); 52 mL (10 g/dL)
115 kg: 90 mL (3 g/dL); 85 mL (4 g/dL); 80 mL (5 g/dL); 75 mL (6 g/dL); 70 mL (7 g/dL); 64 mL (8 g/dL); 59 mL (9 g/dL); 54 mL (10 g/dL)
120 kg: 94 mL (3 g/dL); 88 mL (4 g/dL); 83 mL (5 g/dL); 78 mL (6 g/dL); 73 mL (7 g/dL); 67 mL (8 g/dL); 62 mL (9 g/dL); 57 mL (10 g/dL)
Maximum dose: 2 mL per day
Comments:
Prior to the first therapeutic dose, administer a 0.5 mL test dose; although most reactions are evident within a few minutes, observe patients for at least 1 hour before administering the therapeutic dose.
Discontinue oral iron prior to administration of this product.
Use hemoglobin and hematocrit to monitor response, however iron storage may lag behind normal blood morphology.
Infed(R) may also be administered intramuscularly.
Use: Treatment of documented iron deficiency when oral administration is unsatisfactory or impossible.
Usual Adult Dose for Anemia Associated with Chronic Renal Failure:
Administer doses of 2 mL or less, IV, once a day, until the calculated total amount required has been reached
Replacement iron (in mg) = blood loss (in mL) x hematocrit
Maximum dose: 2 mL per day
Comments:
Iron therapy should replace the equivalent amount of iron represented in the blood loss.
Quantitative estimates of blood loss and hematocrit are needed for dose calculations.
Prior to the first therapeutic dose, administer a 0.5 mL test dose; although most reactions are evident within a few minutes, observe patients for at least 1 hour before administering the therapeutic dose.
Infed(R) may also be administered intramuscularly.
Use: Iron replacement for blood loss, such as periodic losses in hemorrhagic diatheses or repetitive losses such as with hemodialysis.
Usual Pediatric Dose for Iron Deficiency Anemia:
Administer doses of 2 mL or less, IV, once a day, until the calculated total amount required has been reached
15 years and older (15 kg and over):
Dose (mL) = 0.0442 (Desired hemoglobin  Observed hemoglobin) x lean body weight in kg + (0.26 x lean body weight)
Males: Lean Body Weight = 50 kg + 2.3 kg per inch in height over 60 inches
Females: Lean Body Weight = 45.5 kg + 2.3 kg per inch in height over 60 inches
Children 5 to 15 kg: see dosage chart (below)
or
Dose (mL) = 0.0442 (Desired hemoglobin  Observed hemoglobin) x weight in kg + (0.26 x weight)
Desired hemoglobin = target hemoglobin in g/dL; normal hemoglobin for children 15 kg or less is 12 g/dL
OR
Weight in kg: mL drug if Hgb is: 3 g/dL; 4 g/dL; 5 g/dL; 6 g/dL; 7 g/dL; 8 g/dL; 9 g/dL; 10 g/dL
5 kg: 3 mL (3 g/dL); 3 mL (4 g/dL); 3 mL (5 g/dL); 3 mL (6 g/dL); 2 mL (7 g/dL); 2 mL (8 g/dL); 2 mL (9 g/dL); 2 mL (10 g/dL)
10 kg: 7 mL (3 g/dL); 6 mL (4 g/dL); 6 mL (5 g/dL); 5 mL (6 g/dL); 5 mL (7 g/dL); 4 mL (8 g/dL); 4 mL (9 g/dL); 3 mL (10 g/dL)
15 kg: 10 mL (3 g/dL); 9 mL (4 g/dL); 9 mL (5 g/dL); 8 mL (6 g/dL); 7 mL (7 g/dL); 7 mL (8 g/dL); 6 mL (9 g/dL); 5 mL (10 g/dL)
20 kg: 16 mL (3 g/dL); 15 mL (4 g/dL); 14 mL (5 g/dL); 13 mL (6 g/dL); 12 mL (7 g/dL); 11 mL (8 g/dL); 10 mL (9 g/dL); 9 mL (10 g/dL)
25 kg: 20 mL (3 g/dL); 18 mL (4 g/dL); 17 mL (5 g/dL); 16 mL (6 g/dL); 15 mL (7 g/dL); 14 mL (8 g/dL); 13 mL (9 g/dL); 12 mL (10 g/dL)
30 kg: 23 mL (3 g/dL); 22 mL (4 g/dL); 21 mL (5 g/dL); 19 mL (6 g/dL); 18 mL (7 g/dL); 17 mL (8 g/dL); 15 mL (9 g/dL); 14 mL (10 g/dL)
35 kg: 3 mL (3 g/dL); 27 mL (4 g/dL); 26 mL (5 g/dL); 24 mL (6 g/dL); 23 mL (7 g/dL); 20 mL (8 g/dL); 18 mL (9 g/dL); 17 mL (10 g/dL)
40 kg: 31 mL (3 g/dL); 29 mL (4 g/dL); 28 mL (5 g/dL); 26 mL (6 g/dL); 24 mL (7 g/dL); 22 mL (8 g/dL); 21 mL (9 g/dL); 19 mL (10 g/dL)
45 kg: 35 mL (3 g/dL); 35 mL (4 g/dL); 31 mL (5 g/dL); 29 mL (6 g/dL); 27 mL (7 g/dL); 25 mL (8 g/dL); 23 mL (9 g/dL); 21 mL (10 g/dL)
50 kg: 39 mL (3 g/dL); 37 mL (4 g/dL); 35 mL (5 g/dL); 32 mL (6 g/dL); 30 mL (7 g/dL); 28 mL (8 g/dL); 26 mL (9 g/dL); 24 mL (10 g/dL)
55 kg: 43 mL (3 g/dL); 41 mL (4 g/dL); 38 mL (5 g/dL); 36 mL (6 g/dL); 33 mL (7 g/dL); 31 mL (8 g/dL); 28 mL (9 g/dL); 26 mL (10 g/dL)
60 kg: 47 mL (3 g/dL); 44 mL (4 g/dL); 42 mL (5 g/dL); 39 mL (6 g/dL); 36 mL (7 g/dL); 34 mL (8 g/dL); 31 mL (9 g/dL); 28 mL (10 g/dL)
65 kg: 51 mL (3 g/dL); 48 mL (4 g/dL); 45 mL (5 g/dL); 42 mL (6 g/dL); 39 mL (7 g/dL); 36 mL (8 g/dL); 34 mL (9 g/dL); 31 mL (10 g/dL)
70 kg: 55 mL (3 g/dL); 52 mL (4 g/dL); 49 mL (5 g/dL); 45 mL (6 g/dL); 42 mL (7 g/dL); 39 mL (8 g/dL); 36 mL (9 g/dL); 33 mL (10 g/dL)
75 kg: 59 mL (3 g/dL); 55 mL (4 g/dL); 52 mL (5 g/dL); 49 mL (6 g/dL); 45 mL (7 g/dL); 42 mL (8 g/dL); 39 mL (9 g/dL); 35 mL (10 g/dL)
80 kg: 63 mL (3 g/dL); 59 mL (4 g/dL); 55 mL (5 g/dL); 52 mL (6 g/dL); 48 mL (7 g/dL); 45 mL (8 g/dL); 41 mL (9 g/dL); 38 mL (10 g/dL)
85 kg: 66 mL (3 g/dL); 63 mL (4 g/dL); 59 mL (5 g/dL); 55 mL (6 g/dL); 51 mL (7 g/dL); 48 mL (8 g/dL); 44 mL (9 g/dL); 40 mL (10 g/dL)
90 kg: 70 mL (3 g/dL); 66 mL (4 g/dL); 62 mL (5 g/dL); 58 mL (6 g/dL); 54 mL (7 g/dL); 50 mL (8 g/dL); 46 mL (9 g/dL); 42 mL (10 g/dL)
95 kg: 74 mL (3 g/dL); 70 mL (4 g/dL); 66 mL (5 g/dL); 62 mL (6 g/dL); 57 mL (7 g/dL); 53 mL (8 g/dL); 49 mL (9 g/dL); 45 mL (10 g/dL)
100 kg: 78 mL (3 g/dL); 74 mL (4 g/dL); 69 mL (5 g/dL); 65 mL (6 g/dL); 60 mL (7 g/dL); 56 mL (8 g/dL); 52 mL (9 g/dL); 47 mL (10 g/dL)
105 kg: 82 mL (3 g/dL); 77 mL (4 g/dL); 73 mL (5 g/dL); 68 mL (6 g/dL); 63 mL (7 g/dL); 59 mL (8 g/dL); 54 mL (9 g/dL); 10 mL (10 g/dL)
110 kg: 86 mL (3 g/dL); 81 mL (4 g/dL); 76 mL (5 g/dL); 71 mL (6 g/dL); 67 mL (7 g/dL); 62 mL (8 g/dL); 57 mL (9 g/dL); 52 mL (10 g/dL)
115 kg: 90 mL (3 g/dL); 85 mL (4 g/dL); 80 mL (5 g/dL); 75 mL (6 g/dL); 70 mL (7 g/dL); 64 mL (8 g/dL); 59 mL (9 g/dL); 54 mL (10 g/dL)
120 kg: 94 mL (3 g/dL); 88 mL (4 g/dL); 83 mL (5 g/dL); 78 mL (6 g/dL); 73 mL (7 g/dL); 67 mL (8 g/dL); 62 mL (9 g/dL); 57 mL (10 g/dL)
Maximum dose:
Infants under 5 kg: 0.5 mL per day
Children under 10 kg: 1 mL per day
All others: 2 mL per day
Comments:
Prior to the first therapeutic dose, administer a 0.5 mL test dose; although most reactions are evident within a few minutes, observe patients for at least 1 hour before administering the therapeutic dose.
Discontinue oral iron prior to administration of this product.
Use hemoglobin and hematocrit to monitor response, however iron storage may lag behind normal blood morphology.
InFed(R) may also be administered intramuscularly.
Use: Treatment of documented iron deficiency when oral administration is unsatisfactory or impossible.
What other drugs will affect iron dextran?
Other drugs may interact with iron dextran, including prescription and overthecounter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about iron dextran
Consumer resources
Professional resources
Related treatment guides
Where can I get more information?
 Your doctor or pharmacist can provide more information about iron dextran.
 Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
 Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, uptodate, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 19962012 Cerner Multum, Inc. Version: 2.01.
Date modified: October 14, 2016
Last reviewed: May 01, 2014