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Halobetasol and tazarotene topical

Generic name: halobetasol and tazarotene topical [ HAL-oh-BAY-ta-sol-and-ta-ZAR-oh-teen-TOP-i-cal ]
Brand name: Duobrii
Dosage form: topical lotion (0.01%-0.045%)
Drug class: Topical antipsoriatics

Medically reviewed by on May 5, 2023. Written by Cerner Multum.

What is halobetasol and tazarotene topical?

Halobetasol is a highly potent steroid. Tazarotene is a compound similar to vitamin A.

Halobetasol and tazarotene topical (for the skin) is a combination medicine used to treat plaque psoriasis (raised, silvery flaking and redness of the skin) in adults.

Halobetasol and tazarotene topical may also be used for purposes not listed in this medication guide.

Halobetasol and tazarotene topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Halobetasol and tazarotene topical may cause serious side effects. Call your doctor at once if you have:

  • irritation of treated skin;

  • a sunburn;

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;

  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or

  • possible signs of absorbing halobetasol and tazarotene topical through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects of halobetasol and tazarotene topical may include:

  • burning, stinging, redness, itching, pain, or swelling of treated skin;

  • redness or crusting around your hair follicles;

  • rash;

  • peeling skin; or

  • thinning skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Halobetasol and tazarotene topical can cause birth defects. Do not use if you are pregnant. Use effective birth control to prevent pregnancy.

Stop using this medicine and tell your doctor right away if you become pregnant, if you stop using birth control, or if you miss a menstrual period.

Before taking this medicine

You should not use halobetasol and tazarotene topical if you are allergic to halobetasol or tazarotene, or if you are pregnant.

Tell your doctor if you have ever had:

Steroid medicines can increase the glucose (sugar) levels in your blood or urine. Tell your doctor if you have diabetes.

Do not use halobetasol and tazarotene topical if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine.

You may need to have a negative pregnancy test before starting this treatment. You should start using halobetasol and tazarotene topical during a normal menstrual period, to be sure you are not pregnant.

Stop using this medicine and tell your doctor right away if you become pregnant, if you stop using birth control, or if you miss a menstrual period.

It may not be safe to breastfeed while using halobetasol and tazarotene. Ask your doctor about any risk. If you apply this medicine to your chest, avoid areas that may come into contact with the baby's mouth.

This medicine is not approved for use by anyone younger than 18 years old.

How should I use halobetasol and tazarotene topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take by mouth. Topical medicine is for use only on the skin.

If you apply this medicine after taking a shower or bath, dry your skin completely before applying the lotion.

Wash your hands before and after using this medicine, unless you are treating the skin on your hands.

Apply a thin layer of medicine to the affected skin and rub it in gently. Do not apply this medicine over a large area of skin unless your doctor has told you to.

Do not use more than 50 grams of halobetasol and tazarotene topical in 1 week.

Do not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.

Call your doctor if your symptoms do not improve, or if they get worse.

You should stop using the medicine once your skin symptoms are controlled.

Store at room temperature away from moisture and heat. Do not freeze.

Halobetasol and tazarotene topical dosing information

Usual Adult Dose for Plaque Psoriasis:

Apply a thin layer of lotion to the affected area(s) once daily; discontinue therapy when control is achieved

Use: For the topical treatment of plaque psoriasis

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

High doses or long-term use of steroid medicine can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using halobetasol and tazarotene topical?

Do not use on sunburned skin, open wounds, or areas of eczema. Wait until these conditions have fully healed before using halobetasol and tazarotene topical.

Avoid applying halobetasol and tazarotene topical to your face, underarms, or groin area. Avoid getting the medicine in your eyes, mouth, or vagina.

Halobetasol and tazarotene could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect halobetasol and tazarotene topical?

Tell your doctor about all your other medicines, especially:

  • an antibiotic or other medicine that can make your skin more sensitive to sunlight; or

  • any other steroid medicine used on the skin, taken by mouth, or injected.

This list is not complete. Other drugs may affect halobetasol and tazarotene topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

There is no limit on how long you can use Duobrii Lotion, but you should stop using it when your psoriasis has cleared and your doctor tells you to stop treatment. Once your skin is clear it may stay that way for up to 3 months after treatment. Continue reading

Even though Duobrii is a medicine used on the skin, it is highly potent. Excessive doses can pass through your skin and into your bloodstream, which may lead to serious side effects like suppression of your natural cortisol production, Cushing syndrome, high blood sugar or vision problems. Follow your doctor’s dosing instructions exactly. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.