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Chlorpheniramine, codeine, and pseudoephedrine

Generic name: chlorpheniramine, codeine, and pseudoephedrine [ klor-fen-EER-a-meen, KOE-deen, SOO-doe-ee-FED-rin ]
Brand names: Phenylhistine DH Expectorant, Tricode AR, Novahistine DH(obsolete), Phenylhistine DH, Dihistine DH, ... show all 11 brands
Dosage form: oral liquid (2 mg-10 mg-30 mg/5 mL; 2 mg-8 mg-30 mg/5 mL)
Drug class: Upper respiratory combinations

What is chlorpheniramine, codeine, and pseudoephedrine?

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlorpheniramine, codeine, and pseudoephedrine is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.

chlorpheniramine, codeine, and pseudoephedrine will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlorpheniramine, codeine, and pseudoephedrine may also be used for purposes not listed in this medication guide.


Codeine can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

This medicine is not for use in anyone under 18.

Before taking this medicine

You should not use chlorpheniramine, codeine, and pseudoephedrine if you are allergic to codeine, pseudoephedrine, or chlorpheniramine.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

In some people, codeine breaks down rapidly in the liver and reaches higher than normal levels in the body. This can cause dangerously slow breathing and may cause death, especially in a child.

Do not give this medicine to anyone younger than 18 years old.

To make sure this medicine is safe for you, tell your doctor if you have:

If you use codeine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breast-feed. Codeine can pass into breast milk and may cause drowsiness, breathing problems, or death in a nursing baby. Chlorpheniramine may slow breast milk production.

How should I take chlorpheniramine, codeine, and pseudoephedrine?

Follow all directions on your prescription label. Codeine can slow or stop your breathing. Never use chlorpheniramine, codeine, and pseudoephedrine in larger amounts, or for longer than prescribed. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Codeine may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away codeine is against the law.

You should not use antihistamine medication to make a child sleepy.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not take for longer than 7 days in a row. Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days.

Store at room temperature away from moisture and heat. Do not freeze.

Keep track of your medicine. Codeine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since chlorpheniramine, codeine, and pseudoephedrine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A codeine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.

What should I avoid while taking chlorpheniramine, codeine, and pseudoephedrine?

chlorpheniramine, codeine, and pseudoephedrine may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Do not drink alcohol while you are taking medicine that contains codeine. Dangerous side effects or death could occur.

Ask a doctor or pharmacist before using any other cold, allergy, cough, or sleep medicine. Many combination medicines contain antihistamines, decongestants, or cough suppressants. Taking certain products together can cause you to get too much of a certain drug.

Chlorpheniramine, codeine, and pseudoephedrine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medications, codeine can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop taking this medicine and call your doctor at once if you have:

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Common side effects may include:

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Chlorpheniramine, codeine, and pseudoephedrine dosing information

Usual Adult Dose for Cold Symptoms:

Chlorpheniramine 2 mg/codeine 10 mg/pseudoephedrine 30 mg per 5 mL oral liquid:
10 mL orally every 4 hours as needed; not to exceed 4 doses in 24 hours

Chlorpheniramine 2 mg/codeine 8 mg/pseudoephedrine 30 mg per 5 mL oral liquid:
10 mL orally every 4 to 6 hours as needed; not to exceed 40 mL in 24 hours

-Liquid preparations should be measured with an accurate milliliter measuring device.

Uses: For the temporary relief symptoms due to the common cold, hay fever (allergic rhinitis), or other upper respiratory allergies.

What other drugs will affect chlorpheniramine, codeine, and pseudoephedrine?

Ask a doctor or pharmacist before using chlorpheniramine, codeine, and pseudoephedrine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking chlorpheniramine, codeine, and pseudoephedrine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.