Brimonidine and brinzolamide ophthalmic

Generic name: brimonidine and brinzolamide ophthalmic [ bri-MON-i-deen-and-brin-ZOE-la-mide-off-THAL-mik ]
Brand name: Simbrinza
Dosage form: ophthalmic suspension (0.2%-1%)
Drug class: Ophthalmic glaucoma agents

Medically reviewed by Drugs.com on Aug 3, 2023. Written by Cerner Multum.

What is brimonidine and brinzolamide ophthalmic?

Brimonidine and brinzolamide ophthalmic reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Brimonidine and brinzolamide ophthalmic (for the eyes) is a combination medicine used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye).

Brimonidine and brinzolamide ophthalmic may also be used for purposes not listed in this medication guide.

Brimonidine and brinzolamide ophthalmic side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may have other signs of allergic reaction that develop more slowly while using brimonidine and brinzolamide ophthalmic. Call your doctor if you have:

• sudden liver failure--nausea, vomiting, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), confusion, rapid weight gain, (especially in your midsection);

• bone marrow suppression--sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing, pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

• blurred vision, tunnel vision, eye pain, or seeing halos around lights; or

• eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection).

Common side effects of brimonidine and brinzolamide ophthalmic may include:

• blurred vision;

• mild itching, redness, or irritation of your eyes; or

• dry mouth, unpleasant taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

epinephrine ophthalmic, latanoprost ophthalmic, timolol ophthalmic, pilocarpine ophthalmic, brimonidine ophthalmic, Lumigan, Xalatan

Warnings

Brimonidine and brinzolamide ophthalmic should not be given to a child younger than 2 years old.

Before taking this medicine

You should not use brimonidine and brinzolamide ophthalmic if you are allergic to brimonidine or brinzolamide.

Brimonidine and brinzolamide ophthalmic should not be given to a child younger than 2 years old.

To make sure brimonidine and brinzolamide ophthalmic is safe for you, tell your doctor if you have:

• kidney disease;

• liver disease;

• congestive heart failure, coronary artery disease, history of stroke or blood clot;

• high or low blood pressure;

• circulation problems, such as Raynaud's syndrome (numbness or cold feeling in your fingers or toes);

• depression;

• an allergy to sulfa drugs; or

• narrow-angle glaucoma.

FDA pregnancy category C. It is not known whether brimonidine and brinzolamide ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether brimonidine and brinzolamide ophthalmic passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I use brimonidine and brinzolamide ophthalmic?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not use this medication while wearing contact lenses. Brimonidine and brinzolamide ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

Wash your hands before using the eye drops.

Shake the eye drops well just before each use.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.

• Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.

• Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops.

• Wait at least 5 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Tell your doctor right away if you have any eye injury or infection, or if you need to have any type of surgery, especially eye surgery.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

Brimonidine and brinzolamide ophthalmic dosing information

Usual Adult Dose for Intraocular Hypertension:

1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Usual Adult Dose for Glaucoma (Open Angle):

1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Usual Pediatric Dose for Intraocular Hypertension:

2 years or older:
1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Usual Pediatric Dose for Glaucoma (Open Angle):

2 years or older:
1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of brimonidine and brinzolamide ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while taking brimonidine and brinzolamide ophthalmic?

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What other drugs will affect brimonidine and brinzolamide ophthalmic?

Other drugs may interact with brimonidine and brinzolamide ophthalmic, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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