Brimonidine / Brinzolamide Ophthalmic Dosage

Usual Adult Dose for Intraocular Hypertension

1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Usual Adult Dose for Glaucoma (Open Angle)

1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Usual Pediatric Dose for Intraocular Hypertension

2 years or older:
1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Usual Pediatric Dose for Glaucoma (Open Angle)

2 years or older:
1 drop in the affected eye(s) 3 times per day

Comments:
-This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure.
-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: To lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Renal Dose Adjustments

Severe renal impairment (CrCl less than 30 mL/min): Not recommended

Liver Dose Adjustments

Severe hepatic impairment: Use with caution

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug is for topical use only and it is not for injection or oral ingestion.
-Shake well before use.

Patient advice:
-Pressure should be applied to the tear duct immediately following administration of the drug.
-To avoid contamination of the solution, the container should be kept tightly closed.