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Can Soliqua be taken at night?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Sep 12, 2024.

Official answer

by Drugs.com

Key Points

You should inject your Soliqua (insulin glargine and lixisenatide) dose within one hour before your first meal of the day, which for most people will be in the morning before breakfast. If you need to use Soliqua at night, speak with your doctor, who may be able to help you adjust your medication schedule.

Soliqua (insulin glargine and lixisenatide) should be used once a day, at the same time every day. Your doctor will tell you how much Soliqua you need to use each day and can advise you on the best time to use it.

Soliqua contains two medicines: a long-acting insulin glargine and lixisenatide, a glucagon-like peptide-1 (GLP-1) agonist. These medications are used with diet and exercise to help control blood sugar (glucose) in adults with type 2 diabetes.

How is Soliqua given?

Soliqua is given as a subcutaneous injection under the skin. It comes as an autoinjector pen you can use at home. Your doctor, nurse or pharmacist can teach you how to use your pen.

  • Your Soliqua 100/33 pen has a once-daily dose range of 15 to 60 units.
  • Each unit dialed contains 1 unit of insulin glargine and 0.33 micrograms (mcg) of lixisenatide.
  • The maximum dose of Soliqua 100/33 is 60 units daily (60 units insulin glargine/20 mcg lixisenatide). The minimum dose delivered is 15 units daily.
  • When you get your medicine, each carton will hold 5 pens. Each pen should last from 5 to 20 days, depending upon your prescribed dose.

Be sure to follow your doctor’s instruction and take Soliqua exactly as prescribed. Your doctor will prescribe the dose that is right for you.

Related questions

What if I miss my Soliqua dose?

If you miss your dose, take your next scheduled dose at your regular time. Do not double up on your dose or take an extra dose to make up for the dose you missed.

Bottom Line

  • You should inject your Soliqua (insulin glargine and lixisenatide) dose within one hour before your first meal of the day, which for most people will be in the morning before breakfast.
  • If you need to use Soliqua at night, speak with your doctor, who may be able to help you adjust your medication schedule.
  • If you miss your dose, take your next scheduled dose at your regular time. Do not double up on your dose or take an extra dose to make up for the dose you missed.

This is not all the information you need to know about Soliqua 100/33 for safe and effective use. Review the full Soliqua 100/33 information here, and discuss this information with your doctor or other health care provider.

References
  • Soliqua 100/33 [product information]. Nov. 2019. Sanofi-Aventis U.S. LLC
    Bridgewater, NJ. Accessed September 22, 2020 at http://products.sanofi.us/soliqua100-33/Soliqua100-33.pdf

Read next

Does Soliqua cause weight gain?

Weight gain is not a common side effect for Soliqua (insulin glargine/lixisenatide). In some clinical studies, patients using Soliqua had an average weight loss of 0.1 and 0.3 kg (0.2 and 0.7 lb). Continue reading

How long does it take for Soliqua to work?

Soliqua 100/33 is a combination of insulin glargine, a long-acting insulin, and lixisenatide, a GLP-1 receptor agonist. Soliqua starts to lower levels of glucose (sugar) in the blood two hours after injection and keeps working evenly for 20 to 24 hours in most patients. Continue reading

How many units are in a Soliqua pen?

The Soliqua 100/33 pen injector contains 100 units of insulin glargine per one milliliter (mL). It also contains 33 mcg of lixisenatide per mL. Each Soliqua pen holds a total of 3 mL, so there is a total of 300 units of insulin glargine per pen. The maximum dose of Soliqua 100/33 is 60 units daily. Continue reading

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