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Are lung nodules common after Bendeka & Rituxan therapy?

Medically reviewed by Carmen Pope, BPharm. Last updated on May 5, 2025.

Official Answer by Drugs.com

Although there have been a few case reports of interstitial lung disease (ILD) developing following Rituximab (RTX) therapy, it is considered a rare complication of rituximab therapy but one that doctors should monitor for because it may be potentially fatal.

Published case reports mostly reported ILD happening in people taking Rituximab; however, at least two reported the combination of rituximab and bendamustine (Bendeka), for example:

Interstitial Lung Disease (ILD) is an umbrella term for a large group of lung diseases that cause scarring (fibrosis) of the lungs. Scarring makes it difficult to breathe and get oxygen to the bloodstream.

What is a lung nodule?

A lung nodule is a small round or oval solid overgrowth of tissue in the lungs that is seen on an X-ray or computed tomography (CT) scan.

Nodules are common and they show up on about one in every 500 chest x-rays. There may be just one solitary nodule or there may be several. Lung nodules may be benign (noncancerous) or cancerous. Nodules are more likely to be benign if:

References

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