How long does Mavyret stay in your system?

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 7, 2024.

Official Answer by Drugs.com

Mavyret is a medication used to treat chronic hepatitis C virus genotypes 1, 2, 3, 4, 5 or 6 infection in patients without cirrhosis or with compensated cirrhosis.

Mavyret contains two drugs - glecaprevir and pibrentasvir. It takes about 6 hours for your body to get rid of half of a dose of glecaprevir and 13 hours to get rid of half of a dose of pibrentasvir. The time it takes to eliminate half of a dose of a drug from your body is known as its half-life.

It is generally accepted that it takes 5.5 half-lives for a drug to be removed enough from the body that it is thought to have no clinical effect. After taking Mavyret, it’s therefore expected to take 33 hours to eliminate glecaprevir and 71.5 hours to eliminate pibrentasvir.

Mavyret can stay in your system longer if you have severe hepatic (liver) impairment. Mavyret is not used to treat patients with moderate or severe hepatic impairments or those with a history of prior hepatic decompensation (decompensated cirrhosis).

References

Food and Drug Administration (FDA). Mavyret Product Label. June 2021. [Accessed August 17, 2021]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/215110s000,209394s013lbl.pdf.
Hallare J, Gerriets V. Half Life. [Updated 2020 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554498/.

What is the difference between hepatitis B and C?

Some of the main differences between hepatitis B and C are:

Hepatitis B virus can be prevented with a vaccine, but not hepatitis C.
Hepatitis B and C are different viruses, but you can have both hepatitis B and hepatitis C at the same time.
Over 90% of people infected with hepatitis C who have not received treatment can be cured with 8 to 12 weeks of oral medications, but treatment for hepatitis B, if needed, may be long-term or lifelong.
There is no cure for hepatitis B, but once you recover from acute hepatitis B, you develop antibodies that protect you from the virus for life.

What are the new drugs for the treatment of hepatitis C?

The newest drugs for the treatment of hepatitis C include Mavyret (glecaprevir and pibrentasvir), Vosevi (sofosbuvir, velpatasvir, and voxilaprevir), and Epclusa (sofosbuvir and velpatasvir). All are FDA-approved for the treatment of chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A), as well as other uses. In June 2025, Mavyret was approved for the treatment of acute HCV.

How much does Mavyret cost?

The cost of Mavyret for 84 tablets is $14,101 if you are paying cash using the Drugs.com online discount card, however, most people do not pay this amount. If you have commercial insurance, AbbVie offers a $5 per month Copay Savings Card for eligible patients.

How long does Mavyret stay in your system?

Read next

What is the difference between hepatitis B and C?

What are the new drugs for the treatment of hepatitis C?

How much does Mavyret cost?

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